Matches in SemOpenAlex for { <https://semopenalex.org/work/W4211139024> ?p ?o ?g. }
Showing items 1 to 67 of
67
with 100 items per page.
- W4211139024 endingPage "243a" @default.
- W4211139024 startingPage "243a" @default.
- W4211139024 abstract "Acid-sensing ion channels (ASICs) are widely expressed in central nervous system and their activation by protons contributes to synaptic plasticity. Recently, ASICs have gained interest as potential drug targets due to their role in fear and pain processing, ischemic strokes and cardiac pathologies. Detailed functional studies and cryo-EM structures have identified a cluster of protonatable residues in the extracellular domain of the channel, also known as the ‘acidic pocket’. However, due to the limited chemical space accessible by conventional mutagenesis, it remains unknown which amino acids within the acidic pocket contribute to proton-mediated activation." @default.
- W4211139024 created "2022-02-13" @default.
- W4211139024 creator A5041237847 @default.
- W4211139024 creator A5045259945 @default.
- W4211139024 creator A5083238357 @default.
- W4211139024 date "2022-02-01" @default.
- W4211139024 modified "2023-10-14" @default.
- W4211139024 title "Using protein semi-synthesis to identify proton-sensing residues in an acid-sensing ion channel" @default.
- W4211139024 doi "https://doi.org/10.1016/j.bpj.2021.11.1516" @default.
- W4211139024 hasPublicationYear "2022" @default.
- W4211139024 type Work @default.
- W4211139024 citedByCount "0" @default.
- W4211139024 crossrefType "journal-article" @default.
- W4211139024 hasAuthorship W4211139024A5041237847 @default.
- W4211139024 hasAuthorship W4211139024A5045259945 @default.
- W4211139024 hasAuthorship W4211139024A5083238357 @default.
- W4211139024 hasBestOaLocation W42111390241 @default.
- W4211139024 hasConcept C121332964 @default.
- W4211139024 hasConcept C127162648 @default.
- W4211139024 hasConcept C143928317 @default.
- W4211139024 hasConcept C145148216 @default.
- W4211139024 hasConcept C170493617 @default.
- W4211139024 hasConcept C178790620 @default.
- W4211139024 hasConcept C185544564 @default.
- W4211139024 hasConcept C185592680 @default.
- W4211139024 hasConcept C41008148 @default.
- W4211139024 hasConcept C50254741 @default.
- W4211139024 hasConcept C54516573 @default.
- W4211139024 hasConcept C55493867 @default.
- W4211139024 hasConcept C70721500 @default.
- W4211139024 hasConcept C76155785 @default.
- W4211139024 hasConcept C86803240 @default.
- W4211139024 hasConceptScore W4211139024C121332964 @default.
- W4211139024 hasConceptScore W4211139024C127162648 @default.
- W4211139024 hasConceptScore W4211139024C143928317 @default.
- W4211139024 hasConceptScore W4211139024C145148216 @default.
- W4211139024 hasConceptScore W4211139024C170493617 @default.
- W4211139024 hasConceptScore W4211139024C178790620 @default.
- W4211139024 hasConceptScore W4211139024C185544564 @default.
- W4211139024 hasConceptScore W4211139024C185592680 @default.
- W4211139024 hasConceptScore W4211139024C41008148 @default.
- W4211139024 hasConceptScore W4211139024C50254741 @default.
- W4211139024 hasConceptScore W4211139024C54516573 @default.
- W4211139024 hasConceptScore W4211139024C55493867 @default.
- W4211139024 hasConceptScore W4211139024C70721500 @default.
- W4211139024 hasConceptScore W4211139024C76155785 @default.
- W4211139024 hasConceptScore W4211139024C86803240 @default.
- W4211139024 hasIssue "3" @default.
- W4211139024 hasLocation W42111390241 @default.
- W4211139024 hasOpenAccess W4211139024 @default.
- W4211139024 hasPrimaryLocation W42111390241 @default.
- W4211139024 hasRelatedWork W1965237114 @default.
- W4211139024 hasRelatedWork W2035215415 @default.
- W4211139024 hasRelatedWork W2037602302 @default.
- W4211139024 hasRelatedWork W2320403624 @default.
- W4211139024 hasRelatedWork W2378085573 @default.
- W4211139024 hasRelatedWork W2407181204 @default.
- W4211139024 hasRelatedWork W2785993069 @default.
- W4211139024 hasRelatedWork W3136100849 @default.
- W4211139024 hasRelatedWork W4312098035 @default.
- W4211139024 hasRelatedWork W932476301 @default.
- W4211139024 hasVolume "121" @default.
- W4211139024 isParatext "false" @default.
- W4211139024 isRetracted "false" @default.
- W4211139024 workType "article" @default.