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• W4211144080 startingPage "614" @default.
• W4211144080 abstract "Metastatic renal cell carcinoma (RCC) has historically been refractory to cytotoxic and hormonal agents; only interleukin 2 and interferon alpha provide response in a minority of patients. We reviewed RCC biology and explored the ways in which this understanding led to development of novel, effective targeted therapies. Small molecule tyrosine kinase inhibitors, monoclonal antibodies and novel agents are all being studied, and phase II studies show promising activity of sunitinib, sorafenib and bevacizumab. The results of phase III studies will determine the role of these agents in metastatic RCC." @default.
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• W4211144080 date "2006-02-07" @default.
• W4211144080 modified "2023-10-17" @default.
• W4211144080 title "Targeted therapy for metastatic renal cell carcinoma" @default.
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• W4211144080 doi "https://doi.org/10.1038/sj.bjc.6602978" @default.
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