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- W4211148923 endingPage "E253" @default.
- W4211148923 startingPage "E237" @default.
- W4211148923 abstract "Analysis of the interactive effects of combinations of hormones or other manipulations with qualitatively similar individual effects is an important topic in basic and clinical endocrinology as well as other branches of basic and clinical research related to integrative physiology. Functional, as opposed to mechanistic, analyses of interactions rely on the concept of synergy, which can be defined qualitatively as a cooperative action or quantitatively as a supra-additive effect according to some metric for the addition of different dose-effect curves. Unfortunately, dose-effect curve addition is far from straightforward; rather, it requires the development of an axiomatic mathematical theory. I review the mathematical soundness, face validity, and utility of the most frequently used approaches to supra-additive synergy. These criteria highlight serious problems in the two most common synergy approaches, response additivity and Loewe additivity, which is the basis of the isobole and related response surface approaches. I conclude that there is no adequate, generally applicable, supra-additive synergy metric appropriate for endocrinology or any other field of basic and clinical integrative physiology. I recommend that these metrics be abandoned in favor of the simpler definition of synergy as a cooperative, i.e., nonantagonistic, effect. This simple definition avoids mathematical difficulties, is easily applicable, meets regulatory requirements for combination therapy development, and suffices to advance phenomenological basic research to mechanistic studies of interactions and clinical combination therapy research." @default.
- W4211148923 created "2022-02-13" @default.
- W4211148923 creator A5051259319 @default.
- W4211148923 date "2013-02-01" @default.
- W4211148923 modified "2023-09-30" @default.
- W4211148923 title "Understanding synergy" @default.
- W4211148923 cites W1848160003 @default.
- W4211148923 cites W1857006205 @default.
- W4211148923 cites W1962474939 @default.
- W4211148923 cites W1964611857 @default.
- W4211148923 cites W1965321234 @default.
- W4211148923 cites W1971311670 @default.
- W4211148923 cites W1973446897 @default.
- W4211148923 cites W1973511225 @default.
- W4211148923 cites W1975455559 @default.
- W4211148923 cites W1976083063 @default.
- W4211148923 cites W1976276389 @default.
- W4211148923 cites W1978931763 @default.
- W4211148923 cites W1979569154 @default.
- W4211148923 cites W1980796290 @default.
- W4211148923 cites W1983193369 @default.
- W4211148923 cites W1983901940 @default.
- W4211148923 cites W1984225654 @default.
- W4211148923 cites W1985491207 @default.
- W4211148923 cites W1985591463 @default.
- W4211148923 cites W1986453779 @default.
- W4211148923 cites W1987117563 @default.
- W4211148923 cites W1987881399 @default.
- W4211148923 cites W1989054997 @default.
- W4211148923 cites W1990942225 @default.
- W4211148923 cites W1991725476 @default.
- W4211148923 cites W1992513114 @default.
- W4211148923 cites W1992823508 @default.
- W4211148923 cites W1993443139 @default.
- W4211148923 cites W1994663540 @default.
- W4211148923 cites W1995181264 @default.
- W4211148923 cites W1996501896 @default.
- W4211148923 cites W1996634799 @default.
- W4211148923 cites W1998678386 @default.
- W4211148923 cites W1999851917 @default.
- W4211148923 cites W2004306850 @default.
- W4211148923 cites W2004804903 @default.
- W4211148923 cites W2005810270 @default.
- W4211148923 cites W2010384978 @default.
- W4211148923 cites W2010506905 @default.
- W4211148923 cites W2011078148 @default.
- W4211148923 cites W2011202168 @default.
- W4211148923 cites W2011244650 @default.
- W4211148923 cites W2017755517 @default.
- W4211148923 cites W2018438405 @default.
- W4211148923 cites W2019131037 @default.
- W4211148923 cites W2019264664 @default.
- W4211148923 cites W2019750833 @default.
- W4211148923 cites W2021247017 @default.
- W4211148923 cites W2021671843 @default.
- W4211148923 cites W2029701696 @default.
- W4211148923 cites W2031932867 @default.
- W4211148923 cites W2033771027 @default.
- W4211148923 cites W2034514998 @default.
- W4211148923 cites W2034572479 @default.
- W4211148923 cites W2034800901 @default.
- W4211148923 cites W2036445178 @default.
- W4211148923 cites W2036997427 @default.
- W4211148923 cites W2037794724 @default.
- W4211148923 cites W2040400779 @default.
- W4211148923 cites W2041376120 @default.
- W4211148923 cites W2042935282 @default.
- W4211148923 cites W2044025814 @default.
- W4211148923 cites W2046711784 @default.
- W4211148923 cites W2047111229 @default.
- W4211148923 cites W2050259237 @default.
- W4211148923 cites W2053470367 @default.
- W4211148923 cites W2058922633 @default.
- W4211148923 cites W2060737851 @default.
- W4211148923 cites W2061336225 @default.
- W4211148923 cites W2065919617 @default.
- W4211148923 cites W2067862909 @default.
- W4211148923 cites W2069505470 @default.
- W4211148923 cites W2069950551 @default.
- W4211148923 cites W2070935774 @default.
- W4211148923 cites W2074191895 @default.
- W4211148923 cites W2077548379 @default.
- W4211148923 cites W2077620426 @default.
- W4211148923 cites W2077945404 @default.
- W4211148923 cites W2079571554 @default.
- W4211148923 cites W2079757591 @default.
- W4211148923 cites W2081700085 @default.
- W4211148923 cites W2085168287 @default.
- W4211148923 cites W2086042461 @default.
- W4211148923 cites W2087318538 @default.
- W4211148923 cites W2088104656 @default.
- W4211148923 cites W2088283843 @default.
- W4211148923 cites W2089145764 @default.
- W4211148923 cites W2091787052 @default.
- W4211148923 cites W2091902519 @default.
- W4211148923 cites W2092531573 @default.
- W4211148923 cites W2095399601 @default.
- W4211148923 cites W2096780893 @default.