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- W4211152382 endingPage "688" @default.
- W4211152382 startingPage "675" @default.
- W4211152382 abstract "Biliary tract carcinoma is a collective term for a heterogeneous group of rare gastrointestinal cancers including cholangiocarcinoma (intrahepatic, hilar and distal) and gallbladder cancer with different pathogenesis and prognosis. Surgery with complete resection is the only curative chance, but a minority of patients present with resectable disease, but relapse rates are high. Cisplatin/gemcitabine combination chemotherapy represents the first-line reference cytotoxic treatment for patients with advanced/metastatic unresectable disease, while there is no standard second-line therapy. Selected patients may benefit from liver transplantation combined with neoadjuvant chemoradiotherapy or may be suitable for liver-directed therapy (e.g. radioembolization or external beam radiation). Emerging data from next-generation sequencing analyses have identified several genomic alterations (e.g. FGFR fusion rearrangements, IDH-1 and -2 mutations, chromatin modifiers alterations) that are correlated with the disease and potentially druggable by targeted agents. These drugs are currently in early phases of development in BTCs with encouraging results, but further investigation should be warranted to confirm their potential clinical utility." @default.
- W4211152382 created "2022-02-13" @default.
- W4211152382 creator A5008719596 @default.
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- W4211152382 creator A5021735327 @default.
- W4211152382 creator A5055575606 @default.
- W4211152382 creator A5059367989 @default.
- W4211152382 date "2021-01-01" @default.
- W4211152382 modified "2023-09-27" @default.
- W4211152382 title "Biliary Cancer" @default.
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