Matches in SemOpenAlex for { <https://semopenalex.org/work/W4211157073> ?p ?o ?g. }
Showing items 1 to 62 of
62
with 100 items per page.
- W4211157073 abstract "Podocin is a critical component of the glomerular slit diaphragm, and genetic mutations lead to both familial and sporadic forms of steroid-resistant nephrotic syndrome. In mice, constitutive absence of podocin leads to rapidly progressive renal disease characterized by mesangiolysis and/or mesangial sclerosis and nephrotic syndrome. Using established Cre-loxP technology, we inactivated podocin in the adult mouse kidney in a podocyte-specific manner. Progressive loss of podocin in the glomerulus recapitulated albuminuria, hypercholesterolemia, hypertension, and renal failure seen in nephrotic syndrome in humans. Lesions of FSGS appeared after 4 wk, with subsequent development of diffuse glomerulosclerosis and tubulointerstitial damage. Interestingly, conditional inactivation of podocin at birth resulted in a gradient of glomerular lesions, including mesangial proliferation, demonstrating a developmental stage dependence of renal histologic patterns of injury. The development of significant albuminuria in this model occurred only after early and focal foot process effacement had progressed to diffuse involvement, with complete absence of podocin immunolabeling at the slit diaphragm. Finally, we identified novel potential mediators and perturbed molecular pathways, including cellular proliferation, in the course of progression of renal disease leading to glomerulosclerosis, using global gene expression profiling. PMID: 19713307 Funding information This work was supported by: NIDDK NIH HHS, United States Grant ID: DK065409 NIDDK NIH HHS, United States Grant ID: F32 DK065409 Biotechnology and Biological Sciences Research Council, United Kingdom Grant ID: BB/C519670/1" @default.
- W4211157073 created "2022-02-13" @default.
- W4211157073 creator A5018858685 @default.
- W4211157073 date "2009-09-29" @default.
- W4211157073 modified "2023-09-23" @default.
- W4211157073 title "Faculty Opinions recommendation of Podocin inactivation in mature kidneys causes focal segmental glomerulosclerosis and nephrotic syndrome." @default.
- W4211157073 doi "https://doi.org/10.3410/f.1166116.627030" @default.
- W4211157073 hasPublicationYear "2009" @default.
- W4211157073 type Work @default.
- W4211157073 citedByCount "0" @default.
- W4211157073 crossrefType "dataset" @default.
- W4211157073 hasAuthorship W4211157073A5018858685 @default.
- W4211157073 hasConcept C126322002 @default.
- W4211157073 hasConcept C134018914 @default.
- W4211157073 hasConcept C142724271 @default.
- W4211157073 hasConcept C2776174234 @default.
- W4211157073 hasConcept C2776855237 @default.
- W4211157073 hasConcept C2777146197 @default.
- W4211157073 hasConcept C2777390665 @default.
- W4211157073 hasConcept C2777747828 @default.
- W4211157073 hasConcept C2778415529 @default.
- W4211157073 hasConcept C2778930706 @default.
- W4211157073 hasConcept C2779561371 @default.
- W4211157073 hasConcept C2780091579 @default.
- W4211157073 hasConcept C2780199430 @default.
- W4211157073 hasConcept C2780368995 @default.
- W4211157073 hasConcept C2781175652 @default.
- W4211157073 hasConcept C3018201436 @default.
- W4211157073 hasConcept C71924100 @default.
- W4211157073 hasConceptScore W4211157073C126322002 @default.
- W4211157073 hasConceptScore W4211157073C134018914 @default.
- W4211157073 hasConceptScore W4211157073C142724271 @default.
- W4211157073 hasConceptScore W4211157073C2776174234 @default.
- W4211157073 hasConceptScore W4211157073C2776855237 @default.
- W4211157073 hasConceptScore W4211157073C2777146197 @default.
- W4211157073 hasConceptScore W4211157073C2777390665 @default.
- W4211157073 hasConceptScore W4211157073C2777747828 @default.
- W4211157073 hasConceptScore W4211157073C2778415529 @default.
- W4211157073 hasConceptScore W4211157073C2778930706 @default.
- W4211157073 hasConceptScore W4211157073C2779561371 @default.
- W4211157073 hasConceptScore W4211157073C2780091579 @default.
- W4211157073 hasConceptScore W4211157073C2780199430 @default.
- W4211157073 hasConceptScore W4211157073C2780368995 @default.
- W4211157073 hasConceptScore W4211157073C2781175652 @default.
- W4211157073 hasConceptScore W4211157073C3018201436 @default.
- W4211157073 hasConceptScore W4211157073C71924100 @default.
- W4211157073 hasLocation W42111570731 @default.
- W4211157073 hasOpenAccess W4211157073 @default.
- W4211157073 hasPrimaryLocation W42111570731 @default.
- W4211157073 hasRelatedWork W1585747827 @default.
- W4211157073 hasRelatedWork W1988537627 @default.
- W4211157073 hasRelatedWork W1991422362 @default.
- W4211157073 hasRelatedWork W2062184260 @default.
- W4211157073 hasRelatedWork W2161748321 @default.
- W4211157073 hasRelatedWork W2162966735 @default.
- W4211157073 hasRelatedWork W2359486655 @default.
- W4211157073 hasRelatedWork W2623390040 @default.
- W4211157073 hasRelatedWork W3090366279 @default.
- W4211157073 hasRelatedWork W3107075282 @default.
- W4211157073 isParatext "false" @default.
- W4211157073 isRetracted "false" @default.
- W4211157073 workType "dataset" @default.