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- W4211158805 startingPage "540" @default.
- W4211158805 abstract "With the apparent stagnation in the antibiotic discovery and the propagation of multidrug resistance, Helicobacter pylori associated gastric infections are hard to eradicate. In pursuance of alternative medicines, in this study, covalent modification of chitosan (CS) polymer with curcumin (Cur) was accomplished. Proton Nuclear Magnetic Resonance and Fourier Transform Infrared spectroscopy elucidated the covalent interaction between Cur and CS with characteristic peak of imine functional group (C=N). Scanning Electron Microscopy provided visual proof for surface topology, while size and zeta potential values further affirmed the development of curcumin functionalized chitosan nanosystems (Cur-FCNS). The complexation efficiency of CS with Cur was found as 70 ± 3% at an optimal ratio of 5:1 for CS and Cur, respectively. Cur-FCNS developed with ionic gelation and ultrasonication method demonstrated synergistic anti-H. pylori activity in growth-kinetics and anti-biofilm assays, which was superior to free Cur and even chitosan nanosystems. Under simulated gastric conditions, Cur-FCNS revealed cumulative-release of only 16 ± 0.8% till 40 h, which indicated its improved stability to interact with H. pylori. In silico findings affirmed high binding affinity of Cur-FCNS with multiple bacterial virulence factors. Thus, our results affirmed the exceptional potential of Cur-FCNS as next-generation alternative-medicine to treat resistant H. pylori." @default.
- W4211158805 created "2022-02-13" @default.
- W4211158805 creator A5004505970 @default.
- W4211158805 creator A5007212140 @default.
- W4211158805 creator A5041962664 @default.
- W4211158805 creator A5045593961 @default.
- W4211158805 creator A5075538893 @default.
- W4211158805 creator A5083990016 @default.
- W4211158805 date "2022-04-01" @default.
- W4211158805 modified "2023-09-27" @default.
- W4211158805 title "Chitosan-curcumin complexation to develop functionalized nanosystems with enhanced antimicrobial activity against hetero-resistant gastric pathogen" @default.
- W4211158805 cites W1620160353 @default.
- W4211158805 cites W1970374612 @default.
- W4211158805 cites W1974834318 @default.
- W4211158805 cites W1977191081 @default.
- W4211158805 cites W1980111518 @default.
- W4211158805 cites W1981221017 @default.
- W4211158805 cites W1981915387 @default.
- W4211158805 cites W1994294415 @default.
- W4211158805 cites W1997916572 @default.
- W4211158805 cites W1998890138 @default.
- W4211158805 cites W1999645619 @default.
- W4211158805 cites W2027522130 @default.
- W4211158805 cites W2032054182 @default.
- W4211158805 cites W2032732554 @default.
- W4211158805 cites W2035900467 @default.
- W4211158805 cites W2038404983 @default.
- W4211158805 cites W2041609933 @default.
- W4211158805 cites W2042182152 @default.
- W4211158805 cites W2043110235 @default.
- W4211158805 cites W2049966466 @default.
- W4211158805 cites W2053429372 @default.
- W4211158805 cites W2055504944 @default.
- W4211158805 cites W2080928825 @default.
- W4211158805 cites W2083457469 @default.
- W4211158805 cites W2115562910 @default.
- W4211158805 cites W2132747594 @default.
- W4211158805 cites W2144078454 @default.
- W4211158805 cites W2145589079 @default.
- W4211158805 cites W2158121593 @default.
- W4211158805 cites W2165114225 @default.
- W4211158805 cites W2251264873 @default.
- W4211158805 cites W2256096952 @default.
- W4211158805 cites W2274349216 @default.
- W4211158805 cites W2282279332 @default.
- W4211158805 cites W2289145521 @default.
- W4211158805 cites W2299625190 @default.
- W4211158805 cites W2336431425 @default.
- W4211158805 cites W2340155420 @default.
- W4211158805 cites W2345335071 @default.
- W4211158805 cites W2346568101 @default.
- W4211158805 cites W2401076609 @default.
- W4211158805 cites W2404371182 @default.
- W4211158805 cites W2414365196 @default.
- W4211158805 cites W2515968685 @default.
- W4211158805 cites W2547737233 @default.
- W4211158805 cites W2549535358 @default.
- W4211158805 cites W2552047904 @default.
- W4211158805 cites W2552862768 @default.
- W4211158805 cites W2571343759 @default.
- W4211158805 cites W2739189454 @default.
- W4211158805 cites W2741826338 @default.
- W4211158805 cites W2748026825 @default.
- W4211158805 cites W2767583344 @default.
- W4211158805 cites W2768654546 @default.
- W4211158805 cites W2771568002 @default.
- W4211158805 cites W2774500031 @default.
- W4211158805 cites W2783335625 @default.
- W4211158805 cites W2792256546 @default.
- W4211158805 cites W2792569575 @default.
- W4211158805 cites W2793177578 @default.
- W4211158805 cites W2794278535 @default.
- W4211158805 cites W2794280251 @default.
- W4211158805 cites W2797757758 @default.
- W4211158805 cites W2800515747 @default.
- W4211158805 cites W2803705174 @default.
- W4211158805 cites W2808711858 @default.
- W4211158805 cites W2809671428 @default.
- W4211158805 cites W2810872603 @default.
- W4211158805 cites W2883495323 @default.
- W4211158805 cites W2883628459 @default.
- W4211158805 cites W2897261528 @default.
- W4211158805 cites W2897388032 @default.
- W4211158805 cites W2898674491 @default.
- W4211158805 cites W2898870070 @default.
- W4211158805 cites W2899347457 @default.
- W4211158805 cites W2914312081 @default.
- W4211158805 cites W2918800693 @default.
- W4211158805 cites W2925901230 @default.
- W4211158805 cites W2936058203 @default.
- W4211158805 cites W2941511110 @default.
- W4211158805 cites W2941800582 @default.
- W4211158805 cites W2943338024 @default.
- W4211158805 cites W2948408829 @default.
- W4211158805 cites W2954336462 @default.
- W4211158805 cites W2964117438 @default.
- W4211158805 cites W2964992986 @default.
- W4211158805 cites W2965588050 @default.