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- W4211163410 abstract "This chapter discusses the role of chloramphenicol. Chloramphenicol was the first broad-spectrum antibiotic introduced into the medicinal use to inhibit the growth of bacteria, rickettsiae, and organisms of the psittacosis-lymphograniiloma group. Several strains of chloramphenicol-producing Streptomyces have been described in the chapter. In a complex medium, growth and chloramphenicol production are dissociated, but in a defined medium, antibiotic production and growth are closely linked, and in most of the growth phase, cells are exposed to concentrations much higher than the 10 μg/ml, which inhibits the growth of many bacteria. Chloramphenicol is predominantly a bacteriostatic agent, inhibiting the growth of blue-green algae, bacteria, and related prokaryotic organisms. The chapter discusses the derived rules for predicting the effect of structure on biological activity in the chloramphenicol series. It describes the biosynthesis of chloramphenicol, and effect of chloramphenicol on the producing organism. One of the most important aspects of chloramphenicol biosynthesis is the ability of the producing organism to become resistant to concentrations that were originally inhibitory. In vivo, as well as in vitro experiments, shows that chloramphenicol inhibits protein synthesis in Streptomyces 13S." @default.
- W4211163410 created "2022-02-13" @default.
- W4211163410 creator A5027080929 @default.
- W4211163410 date "1972-01-01" @default.
- W4211163410 modified "2023-09-27" @default.
- W4211163410 title "Chloramphenicol" @default.
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