FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4211171286> ?p ?o ?g. }

• W4211171286 abstract "Hereditary angioedema (HAE) is a rare autosomal dominant disease; the most well understood forms concern the haplodeficiency of C1 esterase inhibitor (C1INH) and a gain of function mutation of factor XII (FXII). The acute forms of these conditions are mediated by an excessive bradykinin (BK) formation by plasma kallikrein.A validated LC-MS/MS platform of picomolar sensitivity developed for the analysis of eleven bradykinin-related peptides was applied to the plasma of HAE-C1INH and HAE-FXII sampled during remission.In HAE-C1INH plasma, the concentrations of the relatively stable BK1-5 fragment (mean ± S.E.M.: 12.0 ± 4.2 pmol/L), of BK2-9 (0.7 ± 0.2 pmol/L) and of the sums of BK and its tested fragments (18.0 ± 6.4 pmol/L) are significantly greater than those recorded in the plasma of healthy volunteers (1.9 ± 0.6, 0.03 ± 0.03 and 4.3 ± 0.8 pmol/L, respectively), consistent with the previous evidence of permanent plasma kallikrein activity in this disease. Kinin levels in the plasma of HAE-FXII patients did not differ from controls, suggesting that triggering factors for contact system activation are not active during remission.BK1-5, BK2-9 and the sum of BK and its fragments determined by the sensitive LC-MS/MS technique are proposed as potential biomarkers of HAE-C1INH in remission while this was not applicable to HAE-FXII patients." @default.
• W4211171286 created "2022-02-13" @default.
• W4211171286 creator A5004343189 @default.
• W4211171286 creator A5005505723 @default.
• W4211171286 creator A5033927550 @default.
• W4211171286 creator A5056104569 @default.
• W4211171286 creator A5056753880 @default.
• W4211171286 creator A5066959686 @default.
• W4211171286 creator A5085542999 @default.
• W4211171286 date "2022-02-11" @default.
• W4211171286 modified "2023-10-02" @default.
• W4211171286 title "Picomolar Sensitivity Analysis of Multiple Bradykinin-Related Peptides in the Blood Plasma of Patients With Hereditary Angioedema in Remission: A Pilot Study" @default.
• W4211171286 cites W1519621899 @default.
• W4211171286 cites W1560143001 @default.
• W4211171286 cites W1764686129 @default.
• W4211171286 cites W1777223861 @default.
• W4211171286 cites W1969984674 @default.
• W4211171286 cites W1986749958 @default.
• W4211171286 cites W2031431008 @default.
• W4211171286 cites W2041573479 @default.
• W4211171286 cites W2055068336 @default.
• W4211171286 cites W2059684863 @default.
• W4211171286 cites W2067209814 @default.
• W4211171286 cites W2077187790 @default.
• W4211171286 cites W2105301485 @default.
• W4211171286 cites W2115565372 @default.
• W4211171286 cites W2115789382 @default.
• W4211171286 cites W2121044482 @default.
• W4211171286 cites W2136274885 @default.
• W4211171286 cites W2386081449 @default.
• W4211171286 cites W2416890084 @default.
• W4211171286 cites W2590709005 @default.
• W4211171286 cites W2765459541 @default.
• W4211171286 cites W2883499066 @default.
• W4211171286 cites W2894843000 @default.
• W4211171286 cites W2947028024 @default.
• W4211171286 cites W2969600050 @default.
• W4211171286 cites W2978841203 @default.
• W4211171286 cites W2995370677 @default.
• W4211171286 cites W3024408344 @default.
• W4211171286 cites W3042400458 @default.
• W4211171286 cites W3115426113 @default.
• W4211171286 cites W3133668063 @default.
• W4211171286 cites W3136965065 @default.
• W4211171286 cites W3175550598 @default.
• W4211171286 cites W3185315738 @default.
• W4211171286 cites W4206072950 @default.
• W4211171286 cites W4246423891 @default.
• W4211171286 doi "https://doi.org/10.3389/falgy.2022.837463" @default.
• W4211171286 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35386662" @default.
• W4211171286 hasPublicationYear "2022" @default.
• W4211171286 type Work @default.
• W4211171286 citedByCount "3" @default.
• W4211171286 countsByYear W42111712862022 @default.
• W4211171286 countsByYear W42111712862023 @default.
• W4211171286 crossrefType "journal-article" @default.
• W4211171286 hasAuthorship W4211171286A5004343189 @default.
• W4211171286 hasAuthorship W4211171286A5005505723 @default.
• W4211171286 hasAuthorship W4211171286A5033927550 @default.
• W4211171286 hasAuthorship W4211171286A5056104569 @default.
• W4211171286 hasAuthorship W4211171286A5056753880 @default.
• W4211171286 hasAuthorship W4211171286A5066959686 @default.
• W4211171286 hasAuthorship W4211171286A5085542999 @default.
• W4211171286 hasBestOaLocation W42111712861 @default.
• W4211171286 hasConcept C126322002 @default.
• W4211171286 hasConcept C134018914 @default.
• W4211171286 hasConcept C152328610 @default.
• W4211171286 hasConcept C170493617 @default.
• W4211171286 hasConcept C181199279 @default.
• W4211171286 hasConcept C185592680 @default.
• W4211171286 hasConcept C203014093 @default.
• W4211171286 hasConcept C2776246183 @default.
• W4211171286 hasConcept C2777167447 @default.
• W4211171286 hasConcept C2777788586 @default.
• W4211171286 hasConcept C2777902427 @default.
• W4211171286 hasConcept C2777995640 @default.
• W4211171286 hasConcept C2778382381 @default.
• W4211171286 hasConcept C2779591629 @default.
• W4211171286 hasConcept C2779931649 @default.
• W4211171286 hasConcept C2781317560 @default.
• W4211171286 hasConcept C52853521 @default.
• W4211171286 hasConcept C55493867 @default.
• W4211171286 hasConcept C71924100 @default.
• W4211171286 hasConceptScore W4211171286C126322002 @default.
• W4211171286 hasConceptScore W4211171286C134018914 @default.
• W4211171286 hasConceptScore W4211171286C152328610 @default.
• W4211171286 hasConceptScore W4211171286C170493617 @default.
• W4211171286 hasConceptScore W4211171286C181199279 @default.
• W4211171286 hasConceptScore W4211171286C185592680 @default.
• W4211171286 hasConceptScore W4211171286C203014093 @default.
• W4211171286 hasConceptScore W4211171286C2776246183 @default.
• W4211171286 hasConceptScore W4211171286C2777167447 @default.
• W4211171286 hasConceptScore W4211171286C2777788586 @default.
• W4211171286 hasConceptScore W4211171286C2777902427 @default.
• W4211171286 hasConceptScore W4211171286C2777995640 @default.
• W4211171286 hasConceptScore W4211171286C2778382381 @default.
• W4211171286 hasConceptScore W4211171286C2779591629 @default.
• W4211171286 hasConceptScore W4211171286C2779931649 @default.
• W4211171286 hasConceptScore W4211171286C2781317560 @default.
• W4211171286 hasConceptScore W4211171286C52853521 @default.

• next