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- W4211174661 abstract "The horse mussel Modiolus modiolus (L.) is a sentinel bivalve species used in monitoring programs to assess potential biological exposure to anthropogenic contaminants, including oil hydrocarbons, in benthic environments. In an aquarium based experiment, these mussels were exposed to a simulated oil spill where crude oil at realistic concentrations (from low to high) interacted with an inert environment (seawater, gravel surface, etc.) and the biota. Using a combination of endpoints that included tissue contaminant load, protease activity, antioxidant enzyme activity, and low-molecular antioxidant profiles, we characterized M. modiolus responses to this simulated crude oil spill. Significant differences were observed in tissue protein reserves, protease activity, and oxidative stress markers including glutathione content and glutathione-S-transferase activity in the hepatopancreas and gill tissues of the bivalves treated with oil. Total concentrations of oil-derived polycyclic aromatic hydrocarbons in M. modiolus tissues were generally highest under the highest ambient oil concentration with much lower levels at the lowest. This general pattern does match the activity of protein quality control proteases but not the antioxidant enzyme activity profiles. Glutathione-S-transferase activity in bivalves showed decreased activity under the high compared to the lower oil load and oil-free animals, while glutathione content and calpain activity were positively correlated with oil uptake. The data suggest that these benthic organisms were exhibiting biological responses to the oil polycyclic aromatic hydrocarbons and support the bioindicator value of the species.
 Keywords: M. modiolus, oil spill, PAHs, integrative biomarker approach, protein quality control, GSH, GST" @default.
- W4211174661 created "2022-02-13" @default.
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- W4211174661 date "2022-02-11" @default.
- W4211174661 modified "2023-09-30" @default.
- W4211174661 title "Integrative Biomarker Indices in a Benthic Indicator Species Modiolus Modiolus (L.) Under a Simulated Oil Spill" @default.
- W4211174661 doi "https://doi.org/10.18502/kss.v7i3.10427" @default.
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