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- W4211178483 abstract "The main types of cells participating in rabbit tuberculous lesions are dendritic cells (DCs), macrophages, natural killer (NK) cells, lymphocytes, and granulocytes. Follicular DCs and antigen-activated helper T cells interact with B cells for antibody production. The primary acquired immune response to the tubercle bacillus is initiated by DCs that activate T cells. Macrophages can inhibit or kill intracellular tubercle bacilli by means of reactive nitrogen and oxygen intermediates (RNIs and ROIs), to which M. tuberculosis is exquisitely susceptible. Tubercle bacilli can live for months in mouse granulomas without multiplying and without dying. Macrophages are the major cells of the mononuclear phagocyte system. This system is composed of promonocytes in the bone marrow, monocytes in the circulation, and macrophages in the tissues. Active collagenase (an enzyme secreted but not stored in macrophages) was only detected in fluids from peak BCG lesions. T lymphocytes have been divided into various subsets by their CD4 and CD8 surface antigens, by their functions (T helper [Th] cells, regulatory T cells, and cytotoxic T cells), and by the cytokines they produce (Th1 and Th2). Perforin is a protein that can polymerize to form a hole (or pore) in the target cell's membrane. The eosinophils in rabbit BCG lesions seem to show higher ribonuclease activity than any other cell present. At sites of many infections, mast cell cytokines have been found to enhance the recruitment of T cells. They probably play a similar role in lesions produced by the tubercle bacillus." @default.
- W4211178483 created "2022-02-13" @default.
- W4211178483 date "2014-04-30" @default.
- W4211178483 modified "2023-09-23" @default.
- W4211178483 title "Macrophages and Other Cells in Tuberculous Lesions" @default.
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