FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4211182079> ?p ?o ?g. }

• W4211182079 endingPage "94" @default.
• W4211182079 startingPage "77" @default.
• W4211182079 abstract "Parathyroid cancer (PC) is an uncommon malignant disease, with less than 1,000 cases reported in the literature since de Quervain first described it in 1904 as a non-functional metastatic cancer. With an estimated prevalence of 0.005% of all cancers, PC is the rarest endocrine cancer and accounts for only 0.5-5% of all cases of primary hyperparathyroidism (PHPT). The pathogenesis of PC is unknown. The etiology of PC is not clear and there is no evidence that PC is formed by the transformation of pre-existing parathyroid lesions. The aberrant profile of microRNA expression and methylation recently identified by PCR provides evidence that malignant forms of the parathyroid gland are different from benign lesions. PC may be sporadic or part of a genetic syndrome. Sporadic PC is most often associated with exposure to external radiation, and rarely with secondary and tertiary HPT due to chronic renal failure. The association of PC, synchronous or metachronous, with a history of PT gland hyperplasia, parathyroid adenoma (PA), or thyroid cancer with concomitant PA has also been reported. PC usually presents with indolent but persistent clinical symptoms; patients often show symptoms and complications of severe PHPT such as anxiety, depression, weakness, weight loss, bone and kidney disease, abdominal pain, nausea, pancreatitis, and peptic ulcer. In the investigation series, 50% of patients show manifestations of renal and bone pathology, including osteopenia, osteoporosis, osteoofibrosis, osteitis fibrosa cystica, subperiosteal resorption and pathological fractures. Renal disease manifests mainly as nephrolithiasis and renal failure with a prevalence of 56 and 84%, respectively. It has been observed that serum calcium levels are often higher than 3.5 mmol / l (as opposed to <2.8 mmol / l in benign disease), while serum PTH levels are usually 3 to 10 times higher than the upper normal limit (benign PT). disease may show a more moderate increase), although there is no agreed threshold for PTH and serum calcium levels to define PT malignancy. As with benign disease, visualization is necessary for tumor localization, but it cannot reliably distinguish benign from malignant disease. Several imaging methods, most often a combination of MIBI and ultrasound examination of the neck, increase diagnostic sensitivity and accuracy. Some ultrasound features can predict malignancy and help identify pathological lymph nodes or invasion of nearby structures: a size> 3 cm should cause PC suspicion. Intraoperative findings suspected on PC have been described. In most series, the median maximum PC diameter is 3-3.5 cm (<10% greater than 4 cm), compared to approximately 1.5 cm for PA. 21% of cancers have been reported to have a cystic component. No universal system of clinical and pathological stages for PC has been adopted, because there is no correlation between tumor diameter or lymph node status with survival, and the disease is very rarely diagnosed preoperatively or even intraoperatively. Schulte et al proposed a system of determination based on two classification schemes, a differentiated classification as within the TNM classification and a high-risk / low-risk classification that appears to show significant prediction power for survival or relapse. Historically, almost 96% of PC patients have been treated surgically, and surgery is the only effective therapy to control hypercalcemia, both at initial resection and at the time of metastasis recurrence. Optimal treatment of hypercalcemia is important before surgery. A patient with long unrecognized primary hyperparathyroidism despite the manifestation of classic signs and symptoms of the disease: bilateral nephrocalculosis, hypertension, increased thirst, constipation, depression, pain in the lumbar spine is presented. Upon admission to the Clinic for endocrinology and Metabolic Diseases, biochemical analyzes were performed: eGFR: 46 ml / min / 1.73 m2, calcium: 3.34mmol / l [2.15-2.65], calcium, ionized: 1.89mmol / l [1.15-1.35], phosphorus: 0.74 mmol / l [0.8 - 1.55], magnesium: 0.72 mmol / l, PTH 1276 ng / l, vitamin D 14.2 nmol / l. After emergency therapy of hypercalcemia with bisphosphonates i.v., the patient was referred for surgical treatment due to the fulfillment of operative criteria. extraction of the upper right PT gland was performed, and histopathological findings indicated parathyroid cancer." @default.
• W4211182079 created "2022-02-13" @default.
• W4211182079 creator A5016934893 @default.
• W4211182079 creator A5031713838 @default.
• W4211182079 creator A5062252975 @default.
• W4211182079 creator A5072387666 @default.
• W4211182079 creator A5076324899 @default.
• W4211182079 creator A5078428293 @default.
• W4211182079 creator A5088364835 @default.
• W4211182079 date "2021-01-01" @default.
• W4211182079 modified "2023-10-06" @default.
• W4211182079 title "Paratiroidni karcinom" @default.
• W4211182079 cites W188968753 @default.
• W4211182079 cites W1964811088 @default.
• W4211182079 cites W1976928374 @default.
• W4211182079 cites W1978372123 @default.
• W4211182079 cites W1980108724 @default.
• W4211182079 cites W1981485732 @default.
• W4211182079 cites W1982003016 @default.
• W4211182079 cites W1982498864 @default.
• W4211182079 cites W1985403537 @default.
• W4211182079 cites W1988743571 @default.
• W4211182079 cites W1990033391 @default.
• W4211182079 cites W1990040363 @default.
• W4211182079 cites W1996471655 @default.
• W4211182079 cites W1997641838 @default.
• W4211182079 cites W1998183102 @default.
• W4211182079 cites W2003114494 @default.
• W4211182079 cites W2005089574 @default.
• W4211182079 cites W2005341353 @default.
• W4211182079 cites W2005956955 @default.
• W4211182079 cites W2007248350 @default.
• W4211182079 cites W2011834911 @default.
• W4211182079 cites W2012626622 @default.
• W4211182079 cites W2013219852 @default.
• W4211182079 cites W2016000348 @default.
• W4211182079 cites W2021131253 @default.
• W4211182079 cites W2022752456 @default.
• W4211182079 cites W2022961808 @default.
• W4211182079 cites W2027990618 @default.
• W4211182079 cites W2030526051 @default.
• W4211182079 cites W2033618006 @default.
• W4211182079 cites W2038476947 @default.
• W4211182079 cites W2038954852 @default.
• W4211182079 cites W2039488875 @default.
• W4211182079 cites W2039953693 @default.
• W4211182079 cites W2042392656 @default.
• W4211182079 cites W2046243524 @default.
• W4211182079 cites W2048022401 @default.
• W4211182079 cites W2049996829 @default.
• W4211182079 cites W2050443212 @default.
• W4211182079 cites W2050865843 @default.
• W4211182079 cites W2051024885 @default.
• W4211182079 cites W2053190897 @default.
• W4211182079 cites W2063909056 @default.
• W4211182079 cites W2067165465 @default.
• W4211182079 cites W2069772984 @default.
• W4211182079 cites W2070422397 @default.
• W4211182079 cites W2070635787 @default.
• W4211182079 cites W2072088603 @default.
• W4211182079 cites W2073040100 @default.
• W4211182079 cites W2075746344 @default.
• W4211182079 cites W2076402945 @default.
• W4211182079 cites W2077370216 @default.
• W4211182079 cites W2078062201 @default.
• W4211182079 cites W2078599252 @default.
• W4211182079 cites W2079848468 @default.
• W4211182079 cites W2080518554 @default.
• W4211182079 cites W2083282875 @default.
• W4211182079 cites W2083988901 @default.
• W4211182079 cites W2084252579 @default.
• W4211182079 cites W2086472831 @default.
• W4211182079 cites W2087730167 @default.
• W4211182079 cites W2089462875 @default.
• W4211182079 cites W2096540089 @default.
• W4211182079 cites W2100815977 @default.
• W4211182079 cites W2100977250 @default.
• W4211182079 cites W2104723731 @default.
• W4211182079 cites W2115054276 @default.
• W4211182079 cites W2117513049 @default.
• W4211182079 cites W2117821944 @default.
• W4211182079 cites W2124645214 @default.
• W4211182079 cites W2127537958 @default.
• W4211182079 cites W2139234044 @default.
• W4211182079 cites W2141415904 @default.
• W4211182079 cites W2147037681 @default.
• W4211182079 cites W2150468893 @default.
• W4211182079 cites W2150736858 @default.
• W4211182079 cites W2152117476 @default.
• W4211182079 cites W2157565690 @default.
• W4211182079 cites W2159155304 @default.
• W4211182079 cites W2161892195 @default.
• W4211182079 cites W2163571202 @default.
• W4211182079 cites W2164815880 @default.
• W4211182079 cites W2165923318 @default.
• W4211182079 cites W2166069686 @default.
• W4211182079 cites W2169003763 @default.
• W4211182079 cites W2169037435 @default.

• next