Matches in SemOpenAlex for { <https://semopenalex.org/work/W4211182743> ?p ?o ?g. }
Showing items 1 to 97 of
97
with 100 items per page.
- W4211182743 endingPage "70" @default.
- W4211182743 startingPage "64" @default.
- W4211182743 abstract "Abstract Drug resistance contributes to treatment failure and relapse in acute lymphoblastic leukemia (ALL). G1P3 (also known as IFI6, interferon, alpha-inducible protein 6) has been regarded as an antiapoptotic protein in myeloma cells and contributes to chemoresistance in breast cancer. However, the role of G1P3 in the proliferation and chemosensitivity of ALL is largely unknown. Data from colony formation and bromo-deoxyuridine (BrdU) incorporation assays showed that siRNA-mediated downregulation of G1P3 repressed cell proliferation of glucocorticoids-resistant human leukemic cells (CEM-C1), while overexpression of G1P3 promoted the cell proliferation. Cell apoptosis of CEM-C1 was suppressed by G1P3 overexpression accompanied by a decrease in cleaved caspase-3 and caspase-9. Knockdown of G1P3 increased protein expression of cleaved caspase-3 and caspase-9 to promote the cell apoptosis of CEM-C1. Moreover, silencing of G1P3 reduced cell viability and promoted cell apoptosis of CEM-C1 exposed to dexamethasone. The proapoptotic protein B-cell lymphoma 2 interacting mediator of cell death (Bim) was enhanced by the interference of G1P3 in CEM-C1. Silencing of Bim attenuated G1P3 interference-induced decrease in cell viability and increase in cell apoptosis in CEM-C1 exposed to dexamethasone. Conclusively, knockdown of G1P3 inhibited cell proliferation of ALL and sensitized glucocorticoid-resistant ALL cells to dexamethasone through upregulation of Bim-mediated cell apoptosis." @default.
- W4211182743 created "2022-02-13" @default.
- W4211182743 creator A5008957851 @default.
- W4211182743 creator A5021809579 @default.
- W4211182743 creator A5027863735 @default.
- W4211182743 creator A5034331935 @default.
- W4211182743 creator A5044222936 @default.
- W4211182743 date "2022-01-01" @default.
- W4211182743 modified "2023-09-26" @default.
- W4211182743 title "Knockdown of G1P3 inhibits cell proliferation and enhances the cytotoxicity of dexamethasone in acute lymphoblastic leukemia" @default.
- W4211182743 cites W2017069405 @default.
- W4211182743 cites W2018172208 @default.
- W4211182743 cites W2019654340 @default.
- W4211182743 cites W2051956247 @default.
- W4211182743 cites W2061154433 @default.
- W4211182743 cites W2066845132 @default.
- W4211182743 cites W2118407318 @default.
- W4211182743 cites W2131242974 @default.
- W4211182743 cites W2133402546 @default.
- W4211182743 cites W2159053012 @default.
- W4211182743 cites W2161729741 @default.
- W4211182743 cites W2166913340 @default.
- W4211182743 cites W2321219061 @default.
- W4211182743 cites W2554573836 @default.
- W4211182743 cites W2569712820 @default.
- W4211182743 cites W2590406062 @default.
- W4211182743 cites W2802599306 @default.
- W4211182743 cites W2808557125 @default.
- W4211182743 cites W2942347286 @default.
- W4211182743 cites W2996443588 @default.
- W4211182743 cites W3035686593 @default.
- W4211182743 cites W3045860853 @default.
- W4211182743 cites W3113184829 @default.
- W4211182743 cites W3149465127 @default.
- W4211182743 cites W3177306556 @default.
- W4211182743 cites W3203200636 @default.
- W4211182743 cites W65867874 @default.
- W4211182743 doi "https://doi.org/10.1515/biol-2022-0011" @default.
- W4211182743 hasPublicationYear "2022" @default.
- W4211182743 type Work @default.
- W4211182743 citedByCount "0" @default.
- W4211182743 crossrefType "journal-article" @default.
- W4211182743 hasAuthorship W4211182743A5008957851 @default.
- W4211182743 hasAuthorship W4211182743A5021809579 @default.
- W4211182743 hasAuthorship W4211182743A5027863735 @default.
- W4211182743 hasAuthorship W4211182743A5034331935 @default.
- W4211182743 hasAuthorship W4211182743A5044222936 @default.
- W4211182743 hasBestOaLocation W42111827431 @default.
- W4211182743 hasConcept C104317684 @default.
- W4211182743 hasConcept C119056186 @default.
- W4211182743 hasConcept C127561419 @default.
- W4211182743 hasConcept C1491633281 @default.
- W4211182743 hasConcept C153911025 @default.
- W4211182743 hasConcept C173396325 @default.
- W4211182743 hasConcept C190283241 @default.
- W4211182743 hasConcept C31573885 @default.
- W4211182743 hasConcept C502942594 @default.
- W4211182743 hasConcept C53227056 @default.
- W4211182743 hasConcept C55493867 @default.
- W4211182743 hasConcept C62112901 @default.
- W4211182743 hasConcept C86803240 @default.
- W4211182743 hasConcept C95444343 @default.
- W4211182743 hasConceptScore W4211182743C104317684 @default.
- W4211182743 hasConceptScore W4211182743C119056186 @default.
- W4211182743 hasConceptScore W4211182743C127561419 @default.
- W4211182743 hasConceptScore W4211182743C1491633281 @default.
- W4211182743 hasConceptScore W4211182743C153911025 @default.
- W4211182743 hasConceptScore W4211182743C173396325 @default.
- W4211182743 hasConceptScore W4211182743C190283241 @default.
- W4211182743 hasConceptScore W4211182743C31573885 @default.
- W4211182743 hasConceptScore W4211182743C502942594 @default.
- W4211182743 hasConceptScore W4211182743C53227056 @default.
- W4211182743 hasConceptScore W4211182743C55493867 @default.
- W4211182743 hasConceptScore W4211182743C62112901 @default.
- W4211182743 hasConceptScore W4211182743C86803240 @default.
- W4211182743 hasConceptScore W4211182743C95444343 @default.
- W4211182743 hasIssue "1" @default.
- W4211182743 hasLocation W42111827431 @default.
- W4211182743 hasLocation W42111827432 @default.
- W4211182743 hasOpenAccess W4211182743 @default.
- W4211182743 hasPrimaryLocation W42111827431 @default.
- W4211182743 hasRelatedWork W1983015622 @default.
- W4211182743 hasRelatedWork W2000149980 @default.
- W4211182743 hasRelatedWork W2039201715 @default.
- W4211182743 hasRelatedWork W22134549 @default.
- W4211182743 hasRelatedWork W2375233627 @default.
- W4211182743 hasRelatedWork W2494327966 @default.
- W4211182743 hasRelatedWork W3010357773 @default.
- W4211182743 hasRelatedWork W3154316911 @default.
- W4211182743 hasRelatedWork W3206974297 @default.
- W4211182743 hasRelatedWork W4235347117 @default.
- W4211182743 hasVolume "17" @default.
- W4211182743 isParatext "false" @default.
- W4211182743 isRetracted "false" @default.
- W4211182743 workType "article" @default.