Matches in SemOpenAlex for { <https://semopenalex.org/work/W4211185157> ?p ?o ?g. }
- W4211185157 endingPage "360" @default.
- W4211185157 startingPage "348" @default.
- W4211185157 abstract "Cryoglobulins are immunoglobulins that precipitate in vitro at temperatures less than 37°C and produce organ damage through two main pathways: vascular sludging (hyperviscosity syndrome, mainly in type I cryoglobulinaemia) and immune-mediated mechanisms (principally vasculitis, in mixed cryoglobulinaemia). Cryoglobulinaemia is associated with many illnesses, which can be broadly grouped into infections, autoimmune disorders, and malignancies; the most common cause is infection with hepatitis C virus. Mixed cryoglobulinaemic syndrome is diagnosed when a patient has typical organ involvement (mainly skin, kidney, or peripheral nerve) and circulating cryoglobulins. Cutaneous purpura is the most common manifestation of cryoglobulinaemic vasculitis. The most frequently affected internal organs are the peripheral nerves, kidneys, and joints. The course varies widely and prognosis is influenced by both cryoglobulinaemic damage to vital organs and by comorbidities associated with underlying diseases. More than 90% of cases of cryoglobulinaemia have a known underlying cause; therefore treatment is focused on the cause of the disorder rather than merely symptomatic relief. Studies suggest that both combined or sequential antiviral therapies and targeted biological treatments might be more effective than monotherapy." @default.
- W4211185157 created "2022-02-13" @default.
- W4211185157 creator A5032958317 @default.
- W4211185157 creator A5042482253 @default.
- W4211185157 creator A5059764745 @default.
- W4211185157 creator A5072107532 @default.
- W4211185157 date "2012-01-01" @default.
- W4211185157 modified "2023-10-02" @default.
- W4211185157 title "The cryoglobulinaemias" @default.
- W4211185157 cites W116650463 @default.
- W4211185157 cites W1624220686 @default.
- W4211185157 cites W1906411012 @default.
- W4211185157 cites W1964565854 @default.
- W4211185157 cites W1964985725 @default.
- W4211185157 cites W1965670111 @default.
- W4211185157 cites W1966318213 @default.
- W4211185157 cites W1966780618 @default.
- W4211185157 cites W1975620628 @default.
- W4211185157 cites W1979174109 @default.
- W4211185157 cites W1981190826 @default.
- W4211185157 cites W1982304294 @default.
- W4211185157 cites W1982593049 @default.
- W4211185157 cites W1983576394 @default.
- W4211185157 cites W1985089150 @default.
- W4211185157 cites W1987043014 @default.
- W4211185157 cites W1988458629 @default.
- W4211185157 cites W1989529519 @default.
- W4211185157 cites W1990227093 @default.
- W4211185157 cites W1990576071 @default.
- W4211185157 cites W1992777337 @default.
- W4211185157 cites W1993773295 @default.
- W4211185157 cites W1995624813 @default.
- W4211185157 cites W1995901131 @default.
- W4211185157 cites W1996497815 @default.
- W4211185157 cites W2000590457 @default.
- W4211185157 cites W2001847454 @default.
- W4211185157 cites W2004176705 @default.
- W4211185157 cites W2006309458 @default.
- W4211185157 cites W2007681747 @default.
- W4211185157 cites W2007973442 @default.
- W4211185157 cites W2009076245 @default.
- W4211185157 cites W2010647465 @default.
- W4211185157 cites W2014800939 @default.
- W4211185157 cites W2017113742 @default.
- W4211185157 cites W2019985783 @default.
- W4211185157 cites W2020792694 @default.
- W4211185157 cites W2022648937 @default.
- W4211185157 cites W2022993300 @default.
- W4211185157 cites W2024378737 @default.
- W4211185157 cites W2025840862 @default.
- W4211185157 cites W2026895473 @default.
- W4211185157 cites W2027545702 @default.
- W4211185157 cites W2028453745 @default.
- W4211185157 cites W2029323175 @default.
- W4211185157 cites W2030186927 @default.
- W4211185157 cites W2030502706 @default.
- W4211185157 cites W2038901073 @default.
- W4211185157 cites W2039250075 @default.
- W4211185157 cites W2040537348 @default.
- W4211185157 cites W2042707268 @default.
- W4211185157 cites W2044784043 @default.
- W4211185157 cites W2046757081 @default.
- W4211185157 cites W2046900942 @default.
- W4211185157 cites W2054054115 @default.
- W4211185157 cites W2057102838 @default.
- W4211185157 cites W2057940890 @default.
- W4211185157 cites W2060101755 @default.
- W4211185157 cites W2060706585 @default.
- W4211185157 cites W2060762092 @default.
- W4211185157 cites W2061520297 @default.
- W4211185157 cites W2066385870 @default.
- W4211185157 cites W2073024240 @default.
- W4211185157 cites W2077477264 @default.
- W4211185157 cites W2080132404 @default.
- W4211185157 cites W2085177433 @default.
- W4211185157 cites W2090978265 @default.
- W4211185157 cites W2090987755 @default.
- W4211185157 cites W2093097715 @default.
- W4211185157 cites W2094179168 @default.
- W4211185157 cites W2097557603 @default.
- W4211185157 cites W2100449766 @default.
- W4211185157 cites W2101299701 @default.
- W4211185157 cites W2103449318 @default.
- W4211185157 cites W2110992334 @default.
- W4211185157 cites W2111559593 @default.
- W4211185157 cites W2112234313 @default.
- W4211185157 cites W2112876622 @default.
- W4211185157 cites W2113864802 @default.
- W4211185157 cites W2114790684 @default.
- W4211185157 cites W2114904233 @default.
- W4211185157 cites W2120070988 @default.
- W4211185157 cites W2120706571 @default.
- W4211185157 cites W2123718813 @default.
- W4211185157 cites W2124171861 @default.
- W4211185157 cites W2133838540 @default.
- W4211185157 cites W2134137260 @default.
- W4211185157 cites W2135407654 @default.
- W4211185157 cites W2136247884 @default.