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- W4211185197 endingPage "1709" @default.
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- W4211185197 abstract "Many epidemiologic studies indicate that vitamin D deficiency increases the risk of a variety of cancers and that higher levels of vitamin D are associated with better prognosis and improved outcomes. However, many studies do not find a benefit of vitamin D sufficiency and the reasons for these discrepancies are not clear. Extensive cellular and in vivo research provides a strong rationale and evidence for benefit based on the anti-proliferative, anti-inflammatory and pro-differentiation effects of calcitriol. The anti-cancer effects in cell culture and animal models of cancer strongly support the utility of calcitriol in cancer prevention and treatment. Although its anti-inflammatory activity is proven, multiple molecular pathways of calcitriol action in cancer cells have been identified providing a mechanistic basis for its potential efficacy in cancer. The data suggest that calcitriol has therapeutic and cancer-preventive effects in several malignancies including PCa. The preclinical data provide considerable rationale for continued development of calcitriol or its analogs for cancer therapy. Future clinical trials should be designed using good clinical trial design principles. Such studies may finally provide compelling data to prove whether or not there is a role for calcitriol or its analogs in cancer prevention or therapy." @default.
- W4211185197 created "2022-02-13" @default.
- W4211185197 creator A5005176108 @default.
- W4211185197 creator A5036496348 @default.
- W4211185197 date "2011-01-01" @default.
- W4211185197 modified "2023-09-25" @default.
- W4211185197 title "Vitamin D and Prostate Cancer" @default.
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