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• W4211189167 startingPage "1769" @default.
• W4211189167 abstract "Adenoviruses are large, nonenveloped, icosahedral viruses with a worldwide distribution and a wide degree of genetic heterogeneity. They are responsible for a spectrum of diseases, both end-organ and systemic, affecting both immunocompetent and immunocompromised hosts. Signs and symptoms vary in severity as well, from mild upper respiratory tract infection to life-threatening pulmonary involvement. Rates of infection, morbidity, and mortality are especially high in pediatric hematopoietic stem cell transplantation patients. Diagnostic challenges reflect both the diversity of this agent and its myriad effects and sites of involvement. Methodologies historically have included phenotypic methods, such as cell culture, electron microscopy, antigen detection, and tissue pathology. These have been supplemented more recently by both qualitative and quantitative molecular amplification assays that may be applied both diagnostically and as screening modalities (particularly in high-risk populations). As more-effective therapeutics become available, the early recognition of such infections becomes more critical to optimal patient care." @default.
• W4211189167 created "2022-02-13" @default.
• W4211189167 creator A5019333356 @default.
• W4211189167 creator A5040541255 @default.
• W4211189167 creator A5050709523 @default.
• W4211189167 date "2015-05-26" @default.
• W4211189167 modified "2023-09-25" @default.
• W4211189167 title "Adenoviruses" @default.
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