Matches in SemOpenAlex for { <https://semopenalex.org/work/W4211191859> ?p ?o ?g. }
- W4211191859 abstract "Abstract Small interfering RNA (siRNA) constitutes a promising therapeutic modality supporting the potential functional cure of hepatitis B. A novel ionizable lipidoid nanoparticle (RBP131) and a state-of-the-art lyophilization technology were developed in this study, enabling to deliver siRNA targeting apolipoprotein B (APOB) into the hepatocytes with an ED 50 of 0.05 mg/kg after intravenous injection. In addition, according to the requirements of Investigational New Drug (IND) application, a potent siRNA targeting hepatitis B virus (HBV) was selected and encapsulated with RBP131 to fabricate a therapeutic formulation termed RB-HBV008. Efficacy investigations in transient and transgenic mouse models revealed that the expressions of viral RNAs and antigens (HBsAg and HBeAg), as well as viral DNA, were repressed, dose-dependently and time-dependently at multilog decreasing amplitude, in both circulation and liver tissue. In contrast, entecavir (ETV), the first-line clinically-employed nucleoside analog drug, barely recused the antigen expression, although it triggered as high as 3.50 log reduction of viral DNA, in line with clinical observations. Moreover, the toxicity profiles suggested satisfactory safety outcomes with ten times the therapeutic window. Therefore, this study provides an effective nucleic acid delivery system and a promising RNAi agent for the treatment of hepatitis B." @default.
- W4211191859 created "2022-02-13" @default.
- W4211191859 creator A5037423862 @default.
- W4211191859 creator A5041522420 @default.
- W4211191859 creator A5042675351 @default.
- W4211191859 creator A5044124706 @default.
- W4211191859 creator A5046382309 @default.
- W4211191859 creator A5052833075 @default.
- W4211191859 creator A5055629026 @default.
- W4211191859 creator A5060115275 @default.
- W4211191859 creator A5085187269 @default.
- W4211191859 date "2022-02-11" @default.
- W4211191859 modified "2023-10-18" @default.
- W4211191859 title "Ionizable liposomal siRNA therapeutics enables potent and persistent treatment of Hepatitis B" @default.
- W4211191859 cites W1968949098 @default.
- W4211191859 cites W1978551768 @default.
- W4211191859 cites W2000071382 @default.
- W4211191859 cites W2007706733 @default.
- W4211191859 cites W2023843484 @default.
- W4211191859 cites W2043808971 @default.
- W4211191859 cites W2049233124 @default.
- W4211191859 cites W2060221489 @default.
- W4211191859 cites W2062999279 @default.
- W4211191859 cites W2071030419 @default.
- W4211191859 cites W2078775246 @default.
- W4211191859 cites W2083579463 @default.
- W4211191859 cites W2086919915 @default.
- W4211191859 cites W2089908069 @default.
- W4211191859 cites W2091878182 @default.
- W4211191859 cites W2103169204 @default.
- W4211191859 cites W2106885643 @default.
- W4211191859 cites W2114785561 @default.
- W4211191859 cites W2143741651 @default.
- W4211191859 cites W2143743183 @default.
- W4211191859 cites W2152095262 @default.
- W4211191859 cites W2336184200 @default.
- W4211191859 cites W2460982223 @default.
- W4211191859 cites W2611237260 @default.
- W4211191859 cites W2746762172 @default.
- W4211191859 cites W2757654367 @default.
- W4211191859 cites W2763021074 @default.
- W4211191859 cites W2793070915 @default.
- W4211191859 cites W2793251968 @default.
- W4211191859 cites W2801105435 @default.
- W4211191859 cites W2801167100 @default.
- W4211191859 cites W2802881274 @default.
- W4211191859 cites W2885302348 @default.
- W4211191859 cites W2891559169 @default.
- W4211191859 cites W2893168313 @default.
- W4211191859 cites W2900781853 @default.
- W4211191859 cites W2942046145 @default.
- W4211191859 cites W2969339289 @default.
- W4211191859 cites W2981927057 @default.
- W4211191859 cites W2996691899 @default.
- W4211191859 cites W3009298449 @default.
- W4211191859 cites W3010507616 @default.
- W4211191859 cites W3036363721 @default.
- W4211191859 cites W3037861990 @default.
- W4211191859 cites W3043327933 @default.
- W4211191859 cites W3083855878 @default.
- W4211191859 cites W3087464533 @default.
- W4211191859 cites W3092068755 @default.
- W4211191859 cites W3097334025 @default.
- W4211191859 cites W3103625388 @default.
- W4211191859 cites W3111108034 @default.
- W4211191859 cites W3131828225 @default.
- W4211191859 cites W3157717776 @default.
- W4211191859 cites W3177410587 @default.
- W4211191859 cites W3195752403 @default.
- W4211191859 cites W3198244112 @default.
- W4211191859 cites W3208156916 @default.
- W4211191859 cites W3208971891 @default.
- W4211191859 doi "https://doi.org/10.1038/s41392-021-00859-y" @default.
- W4211191859 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35145057" @default.
- W4211191859 hasPublicationYear "2022" @default.
- W4211191859 type Work @default.
- W4211191859 citedByCount "12" @default.
- W4211191859 countsByYear W42111918592022 @default.
- W4211191859 countsByYear W42111918592023 @default.
- W4211191859 crossrefType "journal-article" @default.
- W4211191859 hasAuthorship W4211191859A5037423862 @default.
- W4211191859 hasAuthorship W4211191859A5041522420 @default.
- W4211191859 hasAuthorship W4211191859A5042675351 @default.
- W4211191859 hasAuthorship W4211191859A5044124706 @default.
- W4211191859 hasAuthorship W4211191859A5046382309 @default.
- W4211191859 hasAuthorship W4211191859A5052833075 @default.
- W4211191859 hasAuthorship W4211191859A5055629026 @default.
- W4211191859 hasAuthorship W4211191859A5060115275 @default.
- W4211191859 hasAuthorship W4211191859A5085187269 @default.
- W4211191859 hasBestOaLocation W42111918591 @default.
- W4211191859 hasConcept C104317684 @default.
- W4211191859 hasConcept C153911025 @default.
- W4211191859 hasConcept C159047783 @default.
- W4211191859 hasConcept C166703698 @default.
- W4211191859 hasConcept C185592680 @default.
- W4211191859 hasConcept C22615655 @default.
- W4211191859 hasConcept C24107716 @default.
- W4211191859 hasConcept C2522874641 @default.
- W4211191859 hasConcept C2775940106 @default.
- W4211191859 hasConcept C2776175608 @default.