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- W4211193669 abstract "Ion channels are ubiquitous cell transducers of environmental stimuli and underpin electrical excitability. Of particular relevance is the six-transmembrane (6TM) family of ion channels, which plays a crucial role in the physiology of almost any organism: differentiation of the ancestral 6TM architecture has allowed an explosion of functional variability, from reporting noxious environmental conditions, to shaping the neuronal action potential, to syncing the beating of the heart. Despite extensive research, little is known about the complex mutational patterns that gave rise to such dramatic functional adaptation events." @default.
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- W4211193669 date "2022-02-01" @default.
- W4211193669 modified "2023-09-26" @default.
- W4211193669 title "Using latent space models to investigate the evolution of ion channels" @default.
- W4211193669 doi "https://doi.org/10.1016/j.bpj.2021.11.2207" @default.
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