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• W4211193730 abstract "The phenotypic plasticity in responses to short-term stress can provide clues for understanding the adaptive fixation mechanism of genetic variation during long-term exposure to extreme environments. However, few studies have compared short-term stress responses with long-term evolutionary patterns; in particular, no interactions between the two processes have been evaluated in high-altitude environment. We performed RNA sequencing in embryo fibroblasts derived from great tits and mice to explore transcriptional responses after exposure to simulated high-altitude environmental stresses. Transcriptional changes of genes associated with metabolic pathways were identified in both bird and mice cells after short-term stress responses. Genomic comparisons among long-term highland tits and mammals and their lowland relatives revealed similar pathways (e.g., metabolic pathways) with that initiated under short-term stress transcriptional responses in vitro. These findings highlight the indicative roles of short-term stress in the long-term adaptation, and adopt common paths to molecular adaptation in mouse and bird cells." @default.
• W4211193730 created "2022-02-13" @default.
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• W4211193730 date "2022-03-01" @default.
• W4211193730 modified "2023-10-16" @default.
• W4211193730 title "Comparison between short-term stress and long-term adaptive responses reveal common paths to molecular adaptation" @default.
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• W4211193730 doi "https://doi.org/10.1016/j.isci.2022.103899" @default.
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