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- W4211194686 abstract "The genus Chlamydia spp. consists of highly specialized prokaryotic bacteria that exhibit a unique biphasic developmental cycle that ensures their survival. Along with Mycoplasma pneumoniae it is probably the most common cause of community-acquired pneumonia in school-aged children and young adults. This agent has been implicated in the development or acceleration of atherosclerosis, asthma, and chronic obstructive pulmonary disease, and recently, it has been linked to Alzheimer's disease (AD) as well. Recent studies using transmission electron microscopy reveal morphologically atypical chlamydial forms in sites of chronic tissue pathology in vivo, concurrent with reverse transcription (RT)-PCR detection of chlamydial rRNA and mRNA transcripts. Although productive chlamydial infection is the norm, multiple studies suggest the presence of nonculturable persistent chlamydial organisms in host tissues. More importantly, these persistent forms are often found in sites of chronic disease. Several studies report the delayed appearance and prolonged carriage of genital tract C. trachomatis strains acquired perinatally. The fact that all species and strains of chlamydiae produce productive infection of appropriate host cells is evidence of their ability to evade phagosome-lysosome fusion. The persistence of chlamydia-specific IgA antibodies has been proposed as a better marker of chronic C. pneumoniae infections, and of chronic C. trachomatis infections as well. Perhaps studies that look at IgA levels in patients with chronic disease in conjunction with immuno-electron microscopy and molecular biological investigations of the patients' tissues would help to confirm both methodologies." @default.
- W4211194686 created "2022-02-13" @default.
- W4211194686 creator A5083764812 @default.
- W4211194686 date "2014-04-08" @default.
- W4211194686 modified "2023-09-23" @default.
- W4211194686 title "Chlamydia spp." @default.
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