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- W4211196708 abstract "Protein structure alignment is a useful tool for comparing proteins with low sequence similarity and improving the quality of downstream analyses for heterogenous sets of protein systems. Many computational methods have been developed to align any two given protein structures using information such as secondary structure and corresponding distance maps. However, while “optimality” can be determined through a combination of heuristics as well as by leveraging previous biological knowledge, there currently lacks a single algorithm that can robustly minimize topological misalignment of tertiary structures, which are ultimately responsible for the biological function of proteins." @default.
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- W4211196708 date "2022-02-01" @default.
- W4211196708 modified "2023-09-30" @default.
- W4211196708 title "Topological approach for sequence-independent protein structure alignment" @default.
- W4211196708 doi "https://doi.org/10.1016/j.bpj.2021.11.2045" @default.
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