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- W4211200049 abstract "Botulinum neurotoxin serotype A (BoNTA) is widely used for treating neuromuscular disorders. Despite of the various marketed products, BoNTA is known to have small therapeutic index ranging from 5 to 15. In the present study, we designed and characterized engineered BoNTA proteins with fusion of cell-penetrating peptides (CPPs). We have shown that CPPs, particularly a recently reported zinc finger protein could improve the cellular uptake and intramuscular therapeutic index of BoNTA. Our study has shed the light on developing next-generation neuromuscular modulators using CPP fusion." @default.
- W4211200049 created "2022-02-13" @default.
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- W4211200049 date "2022-02-11" @default.
- W4211200049 modified "2023-09-26" @default.
- W4211200049 title "Cell-Penetrating Botulinum Neurotoxin Type A With Improved Cellular Uptake and Therapeutic Index" @default.
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- W4211200049 doi "https://doi.org/10.3389/fbioe.2022.828427" @default.
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