FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4211202238> ?p ?o ?g. }

• W4211202238 abstract "Xeroderma Pigmentosum (XP), an autosomal recessive disorder characterized by ultraviolet radiation-induced abnormalities of DNA excision and repair pathways is associated with early development of cutaneous cancers. Intracellular oxidative stress has also been proposed as a contributor to the occurrence of skin cancers. However, little is known about the possible augmentative contributions of chronic inflammation, immune suppression and oxidative stress to the pathogenesis of malignancies associated with other subtypes of XP. This has been addressed in the current study, focused on the measurement of systemic biomarkers of inflammation, immune dysfunction and oxidative damage in XP patients, consisting of XP-C, XP-D and XP-E cases, including those XP-C cases who had already developed multiple skin malignancies. The inflammatory biomarker profile measured in XP patients and healthy control subjects included the cytokines, interleukins (ILs)-2, -4, -6, -10, interferon-γ (IFN- γ) and tumor-necrosis factor-α (TNF-α), the acute phase reactant, C-reactive protein (CRP), and cotinine (as an objective indicator of smoking status). Immune suppression was detected according to the levels of five soluble inhibitory immune checkpoint proteins (CTLA-4, PD-1, PD-L1, LAG-3 and TIM-3), as well as those of vitamin D, while oxidative stress was determined according to the circulating levels of the DNA adduct, 8-hydroxy-2-deoxyguanosine (8-OH-dG). These various biomarkers were measured in plasma using immunofluorimetric, nephelometric and ELISA procedures. Significant elevations in IL-6 (P<0.01) and TNF-α (P<0.0001), but none of the other cytokines, as well as increased levels of all five soluble inhibitory immune checkpoints (P=0.032-P=0.0001) were detected in the plasma of the XP patients. C-reactive protein and vitamin D were increased and decreased, respectively (both P<0.0001), while only one participant had an elevated level of plasma cotinine. Surprisingly, the levels of 8-OH-dG were significantly (P=0.0001) lower in the group of XP patients relative to a group of healthy control subjects. The findings of increased levels of pro-inflammatory cytokines and, in particular, those of the soluble immune checkpoints, in the setting of decreased vitamin D and moderately elevated levels of CRP in XP patients suggest a possible secondary role of ongoing, inflammatory stress and immune suppression in the pathogenesis of XP-associated malignancies." @default.
• W4211202238 created "2022-02-13" @default.
• W4211202238 creator A5004659046 @default.
• W4211202238 creator A5014022994 @default.
• W4211202238 creator A5021461215 @default.
• W4211202238 creator A5023582751 @default.
• W4211202238 creator A5029014575 @default.
• W4211202238 creator A5032395578 @default.
• W4211202238 creator A5035973780 @default.
• W4211202238 creator A5043177871 @default.
• W4211202238 creator A5047024685 @default.
• W4211202238 date "2022-02-11" @default.
• W4211202238 modified "2023-10-14" @default.
• W4211202238 title "Elevated Levels of Soluble CTLA-4, PD-1, PD-L1, LAG-3 and TIM-3 and Systemic Inflammatory Stress as Potential Contributors to Immune Suppression and Generalized Tumorigenesis in a Cohort of South African Xeroderma Pigmentosum Patients" @default.
• W4211202238 cites W1552675949 @default.
• W4211202238 cites W1811917379 @default.
• W4211202238 cites W1976418335 @default.
• W4211202238 cites W1984752955 @default.
• W4211202238 cites W1989317177 @default.
• W4211202238 cites W1993213090 @default.
• W4211202238 cites W2022099770 @default.
• W4211202238 cites W2029127611 @default.
• W4211202238 cites W2029671786 @default.
• W4211202238 cites W2032602228 @default.
• W4211202238 cites W2073125824 @default.
• W4211202238 cites W2078518665 @default.
• W4211202238 cites W2085757616 @default.
• W4211202238 cites W2088623150 @default.
• W4211202238 cites W2099408048 @default.
• W4211202238 cites W2111074957 @default.
• W4211202238 cites W2117692326 @default.
• W4211202238 cites W2131553129 @default.
• W4211202238 cites W2133327838 @default.
• W4211202238 cites W2135820395 @default.
• W4211202238 cites W2137587123 @default.
• W4211202238 cites W2150886023 @default.
• W4211202238 cites W2162333896 @default.
• W4211202238 cites W2164664027 @default.
• W4211202238 cites W2209533549 @default.
• W4211202238 cites W2267145540 @default.
• W4211202238 cites W2324094374 @default.
• W4211202238 cites W2409503508 @default.
• W4211202238 cites W2464331727 @default.
• W4211202238 cites W2603029028 @default.
• W4211202238 cites W2738297779 @default.
• W4211202238 cites W2748170370 @default.
• W4211202238 cites W2789483697 @default.
• W4211202238 cites W2807244621 @default.
• W4211202238 cites W2818611452 @default.
• W4211202238 cites W2888307256 @default.
• W4211202238 cites W2899241249 @default.
• W4211202238 cites W2902775411 @default.
• W4211202238 cites W2914477018 @default.
• W4211202238 cites W2923695362 @default.
• W4211202238 cites W2941697096 @default.
• W4211202238 cites W2947713025 @default.
• W4211202238 cites W2948270187 @default.
• W4211202238 cites W2954044549 @default.
• W4211202238 cites W2954427828 @default.
• W4211202238 cites W2955114691 @default.
• W4211202238 cites W2963936065 @default.
• W4211202238 cites W2971537112 @default.
• W4211202238 cites W2972873235 @default.
• W4211202238 cites W2990157180 @default.
• W4211202238 cites W3022391635 @default.
• W4211202238 cites W3030448313 @default.
• W4211202238 cites W3036937548 @default.
• W4211202238 cites W3103381832 @default.
• W4211202238 cites W3106005610 @default.
• W4211202238 cites W3135369902 @default.
• W4211202238 cites W3160380101 @default.
• W4211202238 cites W3163095986 @default.
• W4211202238 cites W3181943450 @default.
• W4211202238 cites W3197265554 @default.
• W4211202238 cites W658760079 @default.
• W4211202238 cites W89856530 @default.
• W4211202238 cites W2345204864 @default.
• W4211202238 doi "https://doi.org/10.3389/fonc.2022.819790" @default.
• W4211202238 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35223501" @default.
• W4211202238 hasPublicationYear "2022" @default.
• W4211202238 type Work @default.
• W4211202238 citedByCount "3" @default.
• W4211202238 countsByYear W42112022382022 @default.
• W4211202238 countsByYear W42112022382023 @default.
• W4211202238 crossrefType "journal-article" @default.
• W4211202238 hasAuthorship W4211202238A5004659046 @default.
• W4211202238 hasAuthorship W4211202238A5014022994 @default.
• W4211202238 hasAuthorship W4211202238A5021461215 @default.
• W4211202238 hasAuthorship W4211202238A5023582751 @default.
• W4211202238 hasAuthorship W4211202238A5029014575 @default.
• W4211202238 hasAuthorship W4211202238A5032395578 @default.
• W4211202238 hasAuthorship W4211202238A5035973780 @default.
• W4211202238 hasAuthorship W4211202238A5043177871 @default.
• W4211202238 hasAuthorship W4211202238A5047024685 @default.
• W4211202238 hasBestOaLocation W42112022381 @default.
• W4211202238 hasConcept C126322002 @default.
• W4211202238 hasConcept C143425029 @default.
• W4211202238 hasConcept C17991360 @default.
• W4211202238 hasConcept C203014093 @default.
• W4211202238 hasConcept C2776151105 @default.

• next