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- W4211205382 abstract "[4111-54-0] C6H14LiN (MW 107.15) InChI = 1/C6H14N.Li/c1-5(2)7-6(3)4;/h5-6H,1-4H3;/q-1;+1 InChIKey = ZCSHNCUQKCANBX-UHFFFAOYAP (hindered nonnucleophilic strong base used for carbanion generation, especially kinetic enolates,4 α-heteroatom, allylic,5, 6 and aromatic and heteroaromatic carbanions;7-9 unavoidable in organic synthesis) Alternate Name: LDA. Physical Data: powder, melts with decomposition; pKa = 35.7 in THF.3 Solubility: soluble in Et2O, THF, DME, HMPA; unstable above 0 °C in these solvents; stable in hexane or pentane (0.5–0.6 M) at rt for weeks, when not cooled or concentrated;10 the complex with one molecule of THF is soluble in alkanes like cyclohexane and heptane. Form Supplied in: solid; 2.0 M solution in heptane/THF/ethylbenzene stabilized with Mg(i-Pr2N)2; 10 wt % suspension in hexanes; LDA·THF complex, 1.5 M solution in cyclohexane and 2.0 M in heptane. Analysis of Reagent Purity: several titration methods have been described.120 Preparative Methods: generally prepared directly before use from anhydrous Diisopropylamine and commercially available solutions of Butyllithium. Another process, especially useful for the preparation of large quantities, is the reaction of styrene with 2 equiv of Lithium and 2 equiv of i-Pr2NH in Et2O.11 Handling, Storage, and Precautions: very moisture- and air-sensitive, and should always be kept in an inert atmosphere; irritating to the skin and mucous membranes; therefore contact with skin, eyes, and other tissues and organs should be avoided; proper protection is necessary. Use in a fume hood." @default.
- W4211205382 created "2022-02-13" @default.
- W4211205382 creator A5038192078 @default.
- W4211205382 creator A5038386879 @default.
- W4211205382 creator A5044027406 @default.
- W4211205382 creator A5060077739 @default.
- W4211205382 creator A5085784374 @default.
- W4211205382 date "2004-10-15" @default.
- W4211205382 modified "2023-10-18" @default.
- W4211205382 title "Lithium Diisopropylamide" @default.
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