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- W4211206075 abstract "This chapter provides a broad overview of several of the advances in the understanding of the neurobiology of schizophrenia. It first presents the evidence for the neurodevelopmental hypothesis. Abnormalities in key neurotransmitter systems and neural circuits are considered. The uses of intermediate phenotypes, which are measurable traits that may be more proximal to the underlying genetic vulnerabilities, are also discussed. The neurodevelopmental model of schizophrenia posits that schizophrenia results from abnormalities in development that begin in utero and continue through infancy, adolescence, and young adulthood. The chapter talks about developmental abnormalities that are paralleled by developmental disturbances in brain development. Schizophrenia-associated abnormalities in receptor-mediated signaling of neurotransmitters may be secondary to membrane phospholipid dysfunction. Functional MRI (fMRI) studies of schizophrenia have measured regional cerebral blood flow (rCBF) as an index of metabolic activity in areas of interest at rest and while performing specific cognitive tasks." @default.
- W4211206075 created "2022-02-13" @default.
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- W4211206075 date "2015-02-20" @default.
- W4211206075 modified "2023-09-27" @default.
- W4211206075 title "The Neurobiology of Schizophrenia" @default.
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