FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4211206150> ?p ?o ?g. }

• W4211206150 endingPage "1917" @default.
• W4211206150 startingPage "1917" @default.
• W4211206150 abstract "Pathogenic TMPRSS6 variants impairing matriptase-2 function result in inappropriately high hepcidin levels relative to body iron status, leading to iron refractory iron deficiency anemia (IRIDA). As diagnosing IRIDA can be challenging due to its genotypical and phenotypical heterogeneity, we assessed the transferrin saturation (TSAT)/hepcidin ratio to distinguish IRIDA from multi-causal iron deficiency anemia (IDA). We included 20 IRIDA patients from a registry for rare inherited iron disorders and then enrolled 39 controls with IDA due to other causes. Plasma hepcidin-25 levels were measured by standardized isotope dilution mass spectrometry. IDA controls had not received iron therapy in the last 3 months and C-reactive protein levels were <10.0 mg/L. IRIDA patients had significantly lower TSAT/hepcidin ratios compared to IDA controls, median 0.6%/nM (interquartile range, IQR, 0.4-1.1%/nM) and 16.7%/nM (IQR, 12.0-24.0%/nM), respectively. The area under the curve for the TSAT/hepcidin ratio was 1.000 with 100% sensitivity and specificity (95% confidence intervals 84-100% and 91-100%, respectively) at an optimal cut-off point of 5.6%/nM. The TSAT/hepcidin ratio shows excellent performance in discriminating IRIDA from TMPRSS6-unrelated IDA early in the diagnostic work-up of IDA provided that recent iron therapy and moderate-to-severe inflammation are absent. These observations warrant further exploration in a broader IDA population." @default.
• W4211206150 created "2022-02-13" @default.
• W4211206150 creator A5002116439 @default.
• W4211206150 creator A5015372976 @default.
• W4211206150 creator A5015962682 @default.
• W4211206150 creator A5016872773 @default.
• W4211206150 creator A5032602500 @default.
• W4211206150 creator A5036713064 @default.
• W4211206150 creator A5042246779 @default.
• W4211206150 creator A5065413089 @default.
• W4211206150 creator A5066703022 @default.
• W4211206150 creator A5084191249 @default.
• W4211206150 creator A5086860007 @default.
• W4211206150 date "2022-02-08" @default.
• W4211206150 modified "2023-09-27" @default.
• W4211206150 title "Transferrin Saturation/Hepcidin Ratio Discriminates TMPRSS6-Related Iron Refractory Iron Deficiency Anemia from Patients with Multi-Causal Iron Deficiency Anemia" @default.
• W4211206150 cites W1781008050 @default.
• W4211206150 cites W1805394574 @default.
• W4211206150 cites W1917291108 @default.
• W4211206150 cites W1993415721 @default.
• W4211206150 cites W1997813702 @default.
• W4211206150 cites W1999790790 @default.
• W4211206150 cites W2010103787 @default.
• W4211206150 cites W2010940655 @default.
• W4211206150 cites W2012956876 @default.
• W4211206150 cites W2018883732 @default.
• W4211206150 cites W2027624389 @default.
• W4211206150 cites W2044160976 @default.
• W4211206150 cites W2046410714 @default.
• W4211206150 cites W2048448975 @default.
• W4211206150 cites W2051978340 @default.
• W4211206150 cites W2061035099 @default.
• W4211206150 cites W2070319126 @default.
• W4211206150 cites W2101543922 @default.
• W4211206150 cites W2107704801 @default.
• W4211206150 cites W2108481106 @default.
• W4211206150 cites W2121871264 @default.
• W4211206150 cites W2132155262 @default.
• W4211206150 cites W2133275623 @default.
• W4211206150 cites W2166696991 @default.
• W4211206150 cites W2167910235 @default.
• W4211206150 cites W2220231666 @default.
• W4211206150 cites W2343895948 @default.
• W4211206150 cites W2465813189 @default.
• W4211206150 cites W2522074566 @default.
• W4211206150 cites W2576447200 @default.
• W4211206150 cites W2580415908 @default.
• W4211206150 cites W2785817529 @default.
• W4211206150 cites W2808201717 @default.
• W4211206150 cites W2900365689 @default.
• W4211206150 cites W2902581126 @default.
• W4211206150 cites W2909949690 @default.
• W4211206150 cites W2913615892 @default.
• W4211206150 cites W2967031988 @default.
• W4211206150 cites W2985083948 @default.
• W4211206150 cites W3001284059 @default.
• W4211206150 cites W3020992444 @default.
• W4211206150 cites W3091463224 @default.
• W4211206150 cites W4249150518 @default.
• W4211206150 doi "https://doi.org/10.3390/ijms23031917" @default.
• W4211206150 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35163840" @default.
• W4211206150 hasPublicationYear "2022" @default.
• W4211206150 type Work @default.
• W4211206150 citedByCount "3" @default.
• W4211206150 countsByYear W42112061502022 @default.
• W4211206150 crossrefType "journal-article" @default.
• W4211206150 hasAuthorship W4211206150A5002116439 @default.
• W4211206150 hasAuthorship W4211206150A5015372976 @default.
• W4211206150 hasAuthorship W4211206150A5015962682 @default.
• W4211206150 hasAuthorship W4211206150A5016872773 @default.
• W4211206150 hasAuthorship W4211206150A5032602500 @default.
• W4211206150 hasAuthorship W4211206150A5036713064 @default.
• W4211206150 hasAuthorship W4211206150A5042246779 @default.
• W4211206150 hasAuthorship W4211206150A5065413089 @default.
• W4211206150 hasAuthorship W4211206150A5066703022 @default.
• W4211206150 hasAuthorship W4211206150A5084191249 @default.
• W4211206150 hasAuthorship W4211206150A5086860007 @default.
• W4211206150 hasBestOaLocation W42112061501 @default.
• W4211206150 hasConcept C119060515 @default.
• W4211206150 hasConcept C126322002 @default.
• W4211206150 hasConcept C134018914 @default.
• W4211206150 hasConcept C153852466 @default.
• W4211206150 hasConcept C173188278 @default.
• W4211206150 hasConcept C181199279 @default.
• W4211206150 hasConcept C185592680 @default.
• W4211206150 hasConcept C203014093 @default.
• W4211206150 hasConcept C22814914 @default.
• W4211206150 hasConcept C2776485076 @default.
• W4211206150 hasConcept C2776714187 @default.
• W4211206150 hasConcept C2776732101 @default.
• W4211206150 hasConcept C2776768029 @default.
• W4211206150 hasConcept C2777417653 @default.
• W4211206150 hasConcept C2777807008 @default.
• W4211206150 hasConcept C2778248108 @default.
• W4211206150 hasConcept C2778319317 @default.
• W4211206150 hasConcept C3019673199 @default.
• W4211206150 hasConcept C55493867 @default.
• W4211206150 hasConcept C71924100 @default.

• next