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- W4211216258 abstract "Acid-sensing ion channels (ASICs) activate following extracellular acidification that occurs physiologically in synaptic vesicle fusion or pathophysiologically during ischemia. Unsurprisingly, these trimeric cation channels have been shown to contribute to synaptic transmission and are important mediators of cell death during ischemia. In addition to the ionotropic function of ASIC1a, recent evidence suggests that ASIC1a metabotropically signals for cell death via the channel’s intracellular domains (ICDs)." @default.
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- W4211216258 date "2022-02-01" @default.
- W4211216258 modified "2023-09-26" @default.
- W4211216258 title "High-throughput measurement of human ASIC1a intracellular domain environment using genetic code expansion and spectral flow cytometry" @default.
- W4211216258 doi "https://doi.org/10.1016/j.bpj.2021.11.852" @default.
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