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- W4211216780 abstract "Msh4-Msh5 or MutSy belongs to the MutS family of repair proteins that are mainly involved in post-replicative mismatch repair for the purpose of maintaining genome integrity. However, MutSy plays a different role than the other members of its family by facilitating crossover formation during meiotic recombination in many eukaryotic organisms. Failure to form crossovers leads to improper segregation of chromosomes during meiosis, which can lead to infertility and birth defects. Understanding the structural and functional intricacies of this protein can help to elucidate how it functions in crossover formation and meiotic recombination.Previously, our lab has shown that MutSy binds to Holliday junctions (HJ) and HJ-like structures with high affinity, in contrast to DNA duplexes to which the protein binds with 100- fold weaker affinity." @default.
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- W4211216780 date "2022-02-01" @default.
- W4211216780 modified "2023-09-30" @default.
- W4211216780 title "Structural modeling and molecular dynamics simulations of SCMSH4-MSH5 reveal insight to function during meiotic recombination" @default.
- W4211216780 doi "https://doi.org/10.1016/j.bpj.2021.11.1667" @default.
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