Matches in SemOpenAlex for { <https://semopenalex.org/work/W4211224955> ?p ?o ?g. }
Showing items 1 to 97 of
97
with 100 items per page.
- W4211224955 endingPage "100608" @default.
- W4211224955 startingPage "100608" @default.
- W4211224955 abstract "To evaluate the effect of gonadotropin-releasing hormone agonist (GnRHa) pretreatment time on clinical outcomes of patients who underwent endometrial preparation in HRT cycles and the molecular mechanism in frozen-thawed embryo transfer (FET) cycles, we retrospectively chose 1143 cycles and separated four groups. Endometrial tissues were collected from 44 patients who were cancelled on the day of embryo transfer (there were 10 patients refused to collect endometrium) and were tested for endometrial receptivity marker mRNA and miR-124-3p expression. Furthermore, endometrial stromal cells (ESCs) were transfected to investigate the molecular mechanism. The clinical pregnancy rate and live birth rate were significantly high in group B. The endometrial expression of the IL-6 and IL-11 mRNAs was significantly increased in groups with GnRHa pretreatment compared with group A without the GnRHa pretreatment. Similar results were obtained for the endometrial receptivity markers LIF and integrin αvβ3. The groups treated with GnRHa exhibited a progressive and significant time-dependent decrease in the IL-6 and IL-11 mRNA. In contrast, the levels of LIF and integrin αvβ3 expression remained unaltered among group B-D. In addition, transfection of ESCs with miR-124-3p mimics significantly reduced levels of the IL-6 and IL-11 mRNAs and proteins. The luciferase report assay demonstrated that IL-6 and IL-11 is a target gene of miR-124-3p. The results showed that ultra-long GnRHa administration can improve outcomes, especially after 3 cycles of GnRHa pretreatment, and endometrial receptivity through IL-6 and IL-11 expression levels of ESC regulated by the miR-124-3p for patients with HRT, who underwent FET cycles." @default.
- W4211224955 created "2022-02-13" @default.
- W4211224955 creator A5009398662 @default.
- W4211224955 creator A5018991654 @default.
- W4211224955 creator A5026269804 @default.
- W4211224955 creator A5050902669 @default.
- W4211224955 creator A5070243898 @default.
- W4211224955 creator A5081245223 @default.
- W4211224955 date "2022-06-01" @default.
- W4211224955 modified "2023-10-02" @default.
- W4211224955 title "GnRH agonist treatment regulates IL-6 and IL-11 expression in endometrial stromal cells for patients with HRT regiment in frozen embryo transfer cycles" @default.
- W4211224955 cites W2009572781 @default.
- W4211224955 cites W2043904809 @default.
- W4211224955 cites W2080477496 @default.
- W4211224955 cites W2119120508 @default.
- W4211224955 cites W2155334311 @default.
- W4211224955 cites W2381630563 @default.
- W4211224955 cites W2401156811 @default.
- W4211224955 cites W2523138107 @default.
- W4211224955 cites W2582141810 @default.
- W4211224955 cites W2604751601 @default.
- W4211224955 cites W2615276840 @default.
- W4211224955 cites W2769539155 @default.
- W4211224955 cites W2801329157 @default.
- W4211224955 cites W2883676297 @default.
- W4211224955 cites W2897746111 @default.
- W4211224955 cites W2927173694 @default.
- W4211224955 cites W2944808099 @default.
- W4211224955 cites W2949600344 @default.
- W4211224955 cites W2995171469 @default.
- W4211224955 cites W3009213308 @default.
- W4211224955 cites W3011288781 @default.
- W4211224955 doi "https://doi.org/10.1016/j.repbio.2022.100608" @default.
- W4211224955 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35151984" @default.
- W4211224955 hasPublicationYear "2022" @default.
- W4211224955 type Work @default.
- W4211224955 citedByCount "5" @default.
- W4211224955 countsByYear W42112249552022 @default.
- W4211224955 countsByYear W42112249552023 @default.
- W4211224955 crossrefType "journal-article" @default.
- W4211224955 hasAuthorship W4211224955A5009398662 @default.
- W4211224955 hasAuthorship W4211224955A5018991654 @default.
- W4211224955 hasAuthorship W4211224955A5026269804 @default.
- W4211224955 hasAuthorship W4211224955A5050902669 @default.
- W4211224955 hasAuthorship W4211224955A5070243898 @default.
- W4211224955 hasAuthorship W4211224955A5081245223 @default.
- W4211224955 hasConcept C126322002 @default.
- W4211224955 hasConcept C134018914 @default.
- W4211224955 hasConcept C160099875 @default.
- W4211224955 hasConcept C16685009 @default.
- W4211224955 hasConcept C16930146 @default.
- W4211224955 hasConcept C170493617 @default.
- W4211224955 hasConcept C196843134 @default.
- W4211224955 hasConcept C2778938600 @default.
- W4211224955 hasConcept C2779742232 @default.
- W4211224955 hasConcept C54009773 @default.
- W4211224955 hasConcept C54355233 @default.
- W4211224955 hasConcept C71924100 @default.
- W4211224955 hasConcept C81885089 @default.
- W4211224955 hasConcept C86803240 @default.
- W4211224955 hasConcept C95444343 @default.
- W4211224955 hasConceptScore W4211224955C126322002 @default.
- W4211224955 hasConceptScore W4211224955C134018914 @default.
- W4211224955 hasConceptScore W4211224955C160099875 @default.
- W4211224955 hasConceptScore W4211224955C16685009 @default.
- W4211224955 hasConceptScore W4211224955C16930146 @default.
- W4211224955 hasConceptScore W4211224955C170493617 @default.
- W4211224955 hasConceptScore W4211224955C196843134 @default.
- W4211224955 hasConceptScore W4211224955C2778938600 @default.
- W4211224955 hasConceptScore W4211224955C2779742232 @default.
- W4211224955 hasConceptScore W4211224955C54009773 @default.
- W4211224955 hasConceptScore W4211224955C54355233 @default.
- W4211224955 hasConceptScore W4211224955C71924100 @default.
- W4211224955 hasConceptScore W4211224955C81885089 @default.
- W4211224955 hasConceptScore W4211224955C86803240 @default.
- W4211224955 hasConceptScore W4211224955C95444343 @default.
- W4211224955 hasIssue "2" @default.
- W4211224955 hasLocation W42112249551 @default.
- W4211224955 hasLocation W42112249552 @default.
- W4211224955 hasOpenAccess W4211224955 @default.
- W4211224955 hasPrimaryLocation W42112249551 @default.
- W4211224955 hasRelatedWork W1597151753 @default.
- W4211224955 hasRelatedWork W1877152454 @default.
- W4211224955 hasRelatedWork W1968634370 @default.
- W4211224955 hasRelatedWork W1988322245 @default.
- W4211224955 hasRelatedWork W2027913950 @default.
- W4211224955 hasRelatedWork W2028293475 @default.
- W4211224955 hasRelatedWork W2050423574 @default.
- W4211224955 hasRelatedWork W2058205365 @default.
- W4211224955 hasRelatedWork W2070611629 @default.
- W4211224955 hasRelatedWork W2354292814 @default.
- W4211224955 hasVolume "22" @default.
- W4211224955 isParatext "false" @default.
- W4211224955 isRetracted "false" @default.
- W4211224955 workType "article" @default.