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- W4211227899 endingPage "988" @default.
- W4211227899 startingPage "949" @default.
- W4211227899 abstract "Hirschsprung's disease (HSCR) is a developmental disorder of the enteric nervous system (ENS) derived from neural crest cells (NCCs), which affects their migration, proliferation, differentiation, or preservation in the digestive tract, resulting in aganglionosis in the distal intestine. The regulation of both NCCs and the surrounding environment involves various genes, signaling pathways, transcription factors, and morphogens. Therefore, changes in gene expression during the development of the ENS may contribute to the pathogenesis of HSCR.This review discusses several mechanisms involved in the development of ENS, confirming that deviant genetic and epigenetic patterns, such as DNA methylation, histone modification, and microRNA (miRNA) regulation, can contribute to the development of neurocristopathy. Specifically, the epigenetic regulation of miRNA expression and its relationship to cellular interactions and gene activation through various major pathways in Hirschsprung's disease will be discussed." @default.
- W4211227899 created "2022-02-13" @default.
- W4211227899 creator A5058409470 @default.
- W4211227899 creator A5065599416 @default.
- W4211227899 date "2004-12-01" @default.
- W4211227899 modified "2023-10-16" @default.
- W4211227899 title "Hirschsprung disease" @default.
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