FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4211229722> ?p ?o ?g. }

• W4211229722 endingPage "53" @default.
• W4211229722 startingPage "47" @default.
• W4211229722 abstract "Background . Vasopressin, in cooperative interaction with angiotensin II, participates in cardiovascular regulation and it increases in arterial hypertension. In addition, vasopressin is involved in tumorigenesis through angiogenesis by stimulating protein synthesis in endothelial cells, induction of endothelin-1, influencing cell proliferation, and stimulating growth factors through VIA receptors in the kidneys. To assess the content of vasopressin, a measurement of copeptin, its precursor, produced in an equimolar ratio, is used. Objective : to determine the content of serum copeptin and to reveal correlations with the indices of the renin-angiotensin system in the tumor and blood serum in patients with localized kidney cancer (КС) with arterial hypertension (AH). Materials and methods . The inclusion criteria for the study were initially diagnosed localized KC T1N0M0 without special treatment, age less than 75 years, essential AH of I—II degree without treatment, controlled by angiotensin-converting enzyme inhibitors (ACEi). All patients were divided into groups: patients with KC ( n = 42); KC + AH without treatment (n = 31); KC + AH + ACEi ( n = 32). Serum levels of copeptin and angiotensin I, II, 1-7 and angiotensin-converting enzyme, angiotensin-converting enzyme 2 were determined by ELISA. Also, the level of components of the renin-angiotensin system was assessed in tumor tissue samples obtained by robotic-assisted kidney resection. Results and conclusion . In patients of the KC + AH group, the median of the indicator is statistically significantly higher than in the group of healthy donors (2.4 times at p <0.05). In the group KC + AH + ACEi, a decrease in the content of the studied indicator was found in comparison with the norm by 1.2 times (at p <0.05). It was found that the content of copeptin in the tumor less than 4 cm in comparison with the size of 4-7 cm is significantly lower (KC p = 0.045, KC + AH p = 0.067 and KC + AH + ACEi p = 0.036). Correlation analysis showed direct significant links between high density between the levels of copeptin and angiotensin II in the tumor and blood, and moderate tightness with tumor and serum levels of angiotensin (1-7). Multiple regression analysis revealed that the most significant factors that have a positive effect on the concentration of serum copeptin are the content of angiotensin II in the tumor and blood serum, the tumor concentration of angiotensin (1-7) and angiotensin-converting enzyme 2, as well as the level of systolic blood pressure ( p <0.05)." @default.
• W4211229722 created "2022-02-13" @default.
• W4211229722 creator A5017806443 @default.
• W4211229722 creator A5041908971 @default.
• W4211229722 creator A5055237571 @default.
• W4211229722 creator A5061404024 @default.
• W4211229722 creator A5080051979 @default.
• W4211229722 creator A5080407966 @default.
• W4211229722 date "2022-02-10" @default.
• W4211229722 modified "2023-10-14" @default.
• W4211229722 title "Assessment of the state and relationship of vasopressor and renin-angiotensin systems in patients with localized kidney cancer on the background of arterial hypertension" @default.
• W4211229722 cites W1601916319 @default.
• W4211229722 cites W2054397100 @default.
• W4211229722 cites W2056587840 @default.
• W4211229722 cites W2087838179 @default.
• W4211229722 cites W2128507230 @default.
• W4211229722 cites W2135376590 @default.
• W4211229722 cites W2144352652 @default.
• W4211229722 cites W2156557061 @default.
• W4211229722 cites W2174747373 @default.
• W4211229722 cites W2260136992 @default.
• W4211229722 cites W2443431558 @default.
• W4211229722 cites W2468120791 @default.
• W4211229722 cites W2470332690 @default.
• W4211229722 cites W2601056010 @default.
• W4211229722 cites W2747275153 @default.
• W4211229722 cites W2747789618 @default.
• W4211229722 cites W2800190471 @default.
• W4211229722 cites W3017465916 @default.
• W4211229722 doi "https://doi.org/10.17650/1726-9776-2021-17-4-47-53" @default.
• W4211229722 hasPublicationYear "2022" @default.
• W4211229722 type Work @default.
• W4211229722 citedByCount "0" @default.
• W4211229722 crossrefType "journal-article" @default.
• W4211229722 hasAuthorship W4211229722A5017806443 @default.
• W4211229722 hasAuthorship W4211229722A5041908971 @default.
• W4211229722 hasAuthorship W4211229722A5055237571 @default.
• W4211229722 hasAuthorship W4211229722A5061404024 @default.
• W4211229722 hasAuthorship W4211229722A5080051979 @default.
• W4211229722 hasAuthorship W4211229722A5080407966 @default.
• W4211229722 hasBestOaLocation W42112297221 @default.
• W4211229722 hasConcept C121608353 @default.
• W4211229722 hasConcept C126322002 @default.
• W4211229722 hasConcept C126894567 @default.
• W4211229722 hasConcept C134018914 @default.
• W4211229722 hasConcept C198710026 @default.
• W4211229722 hasConcept C27016395 @default.
• W4211229722 hasConcept C2776370428 @default.
• W4211229722 hasConcept C2779311642 @default.
• W4211229722 hasConcept C2780091579 @default.
• W4211229722 hasConcept C2908929049 @default.
• W4211229722 hasConcept C71924100 @default.
• W4211229722 hasConcept C84393581 @default.
• W4211229722 hasConceptScore W4211229722C121608353 @default.
• W4211229722 hasConceptScore W4211229722C126322002 @default.
• W4211229722 hasConceptScore W4211229722C126894567 @default.
• W4211229722 hasConceptScore W4211229722C134018914 @default.
• W4211229722 hasConceptScore W4211229722C198710026 @default.
• W4211229722 hasConceptScore W4211229722C27016395 @default.
• W4211229722 hasConceptScore W4211229722C2776370428 @default.
• W4211229722 hasConceptScore W4211229722C2779311642 @default.
• W4211229722 hasConceptScore W4211229722C2780091579 @default.
• W4211229722 hasConceptScore W4211229722C2908929049 @default.
• W4211229722 hasConceptScore W4211229722C71924100 @default.
• W4211229722 hasConceptScore W4211229722C84393581 @default.
• W4211229722 hasIssue "4" @default.
• W4211229722 hasLocation W42112297221 @default.
• W4211229722 hasOpenAccess W4211229722 @default.
• W4211229722 hasPrimaryLocation W42112297221 @default.
• W4211229722 hasRelatedWork W1891220646 @default.
• W4211229722 hasRelatedWork W1975291885 @default.
• W4211229722 hasRelatedWork W2016647631 @default.
• W4211229722 hasRelatedWork W2019938707 @default.
• W4211229722 hasRelatedWork W2042660006 @default.
• W4211229722 hasRelatedWork W2069855804 @default.
• W4211229722 hasRelatedWork W2125221738 @default.
• W4211229722 hasRelatedWork W2126797993 @default.
• W4211229722 hasRelatedWork W4211229722 @default.
• W4211229722 hasRelatedWork W1996764561 @default.
• W4211229722 hasVolume "17" @default.
• W4211229722 isParatext "false" @default.
• W4211229722 isRetracted "false" @default.
• W4211229722 workType "article" @default.