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- W4211233926 abstract "Bone-resorbing osteoclasts are essential for life-long skeletal remodeling, and perturbations in their activity contribute to bone diseases afflicting >200 million. Treating resorptive bone diseases has focused on suppressing osteoclast development. Here we share a novel target at the cells’ surface that shifts this paradigm by instead tuning the formation and function of osteoclasts at the mechanistic stage of cell-cell fusion. The fusion of precursors produces multinucleated osteoclasts, and each successive fusion event increases an osteoclast’s resorptive capacity." @default.
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- W4211233926 date "2022-02-01" @default.
- W4211233926 modified "2023-09-30" @default.
- W4211233926 title "Cell surface-bound La protein regulates the cell fusion stage of osteoclastogenesis" @default.
- W4211233926 doi "https://doi.org/10.1016/j.bpj.2021.11.2340" @default.
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