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- W4211234520 endingPage "520" @default.
- W4211234520 startingPage "485" @default.
- W4211234520 abstract "Precise homeostatic control of the interstitial fluid is absolutely critical for normal function of the central nervous system (CNS). The importance of this goal is reflected in the unique priority given to regulation of blood flow and permeability of blood vessels within the brain and spinal cord. Both the morphology and the function of the CNS microcirculation are uniquely adapted to this objective. The structure and function of the cerebral microvessels are uniquely adapted to meet the specialized needs of the CNS. The mechanisms contributing to the regulation of blood flow in the CNS are extremely complex. In addition to specialized adaptations of the metabolic, myogenic and endothelial control mechanisms, there are unique aspects of neural control. Astrocytes have been recently recognized to make pivotal contributions to the rapid and exquisite coupling between changes in neuronal activity and regulation of cerebral blood flow. There is a bi-directional communication among neurons, glia, and microvessels which are now viewed to function as a neurovascular unit. The sensitivity of neurons to alterations in the ionic composition of the extracellular fluid also places unique requirements for the control of vascular permeability. The structural and functional components of the “blood–brain barrier” (BBB) provide this protection with the extremely intricate regulation of permeability. There are also unique limitations to the movement of cellular elements across the BBB. Alteration in both the structure and the function of the cerebral microcirculation associated with aging and neurodegenerative disease leading to compromised adaptability is also an area of active interest." @default.
- W4211234520 created "2022-02-13" @default.
- W4211234520 creator A5076081812 @default.
- W4211234520 date "2008-01-01" @default.
- W4211234520 modified "2023-09-27" @default.
- W4211234520 title "The Cerebral Microcirculation" @default.
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