Matches in SemOpenAlex for { <https://semopenalex.org/work/W4211246615> ?p ?o ?g. }
- W4211246615 abstract "Abstract Purple acid phosphatases (PAPs) hydrolyzing activated phosphoric acid esters and anhydrides have in common a two‐metal center with a tyrosine‐Fe(III) charge transfer transition responsible for the color. In the mammalian enzymes from the spleen, macrophages, osteoclasts, and uterine fluids, the second metal in the active site is Fe(II); whereas, the plant enzyme kidney bean PAP (kbPAP) has an Fe(III)–Zn(II) active center. The structure of the homodimeric 111‐kDa kbPAP shows the active site at the carboxy end of two sandwiched β–α–β–α–β motifs. The two metal ions are bridged monodentately by Asp164. The iron is further coordinated by Tyr167, His325, and Asp135, and the zinc by His286, His323, and Asn201. The active‐site structure is consistent with proposals on the mechanism of phosphate ester hydrolysis by nucleophilic attack on the phosphate by an Fe(III)‐coordinated hydroxide ion. Protein isolation, biological functions, sequences, activity, comparison of mammalian and plant PAPs, and the functional aspects of both types are discussed extensively." @default.
- W4211246615 created "2022-02-13" @default.
- W4211246615 creator A5023155028 @default.
- W4211246615 creator A5058185208 @default.
- W4211246615 creator A5078325680 @default.
- W4211246615 date "2004-03-05" @default.
- W4211246615 modified "2023-10-18" @default.
- W4211246615 title "Purple Acid Phosphatase" @default.
- W4211246615 cites W121022101 @default.
- W4211246615 cites W122728560 @default.
- W4211246615 cites W1486803151 @default.
- W4211246615 cites W1499696220 @default.
- W4211246615 cites W1499971966 @default.
- W4211246615 cites W1502153098 @default.
- W4211246615 cites W1511804083 @default.
- W4211246615 cites W1515122089 @default.
- W4211246615 cites W154228731 @default.
- W4211246615 cites W1545953723 @default.
- W4211246615 cites W1554724146 @default.
- W4211246615 cites W1571380461 @default.
- W4211246615 cites W1572305446 @default.
- W4211246615 cites W1576378802 @default.
- W4211246615 cites W1580813094 @default.
- W4211246615 cites W1581754894 @default.
- W4211246615 cites W1589594958 @default.
- W4211246615 cites W1590478241 @default.
- W4211246615 cites W1594666006 @default.
- W4211246615 cites W1596570698 @default.
- W4211246615 cites W1608092708 @default.
- W4211246615 cites W1681781823 @default.
- W4211246615 cites W1761751741 @default.
- W4211246615 cites W1822169786 @default.
- W4211246615 cites W1823025905 @default.
- W4211246615 cites W1845439488 @default.
- W4211246615 cites W1943108778 @default.
- W4211246615 cites W1963821971 @default.
- W4211246615 cites W1966631093 @default.
- W4211246615 cites W1966940582 @default.
- W4211246615 cites W1968592306 @default.
- W4211246615 cites W1973033788 @default.
- W4211246615 cites W1976086327 @default.
- W4211246615 cites W1976715154 @default.
- W4211246615 cites W1978493698 @default.
- W4211246615 cites W1979661087 @default.
- W4211246615 cites W1979896323 @default.
- W4211246615 cites W1984928131 @default.
- W4211246615 cites W1986441400 @default.
- W4211246615 cites W1988166540 @default.
- W4211246615 cites W1988672276 @default.
- W4211246615 cites W1989019120 @default.
- W4211246615 cites W1989980254 @default.
- W4211246615 cites W1990223180 @default.
- W4211246615 cites W1992367607 @default.
- W4211246615 cites W1995523264 @default.
- W4211246615 cites W1997304859 @default.
- W4211246615 cites W1997697459 @default.
- W4211246615 cites W1999368932 @default.
- W4211246615 cites W1999424299 @default.
- W4211246615 cites W2004810200 @default.
- W4211246615 cites W2006128611 @default.
- W4211246615 cites W2008966915 @default.
- W4211246615 cites W2013873050 @default.
- W4211246615 cites W2016097286 @default.
- W4211246615 cites W2017481744 @default.
- W4211246615 cites W2017626292 @default.
- W4211246615 cites W2018006157 @default.
- W4211246615 cites W2019886699 @default.
- W4211246615 cites W2020386376 @default.
- W4211246615 cites W2021770929 @default.
- W4211246615 cites W2022866008 @default.
- W4211246615 cites W2024269893 @default.
- W4211246615 cites W2024469777 @default.
- W4211246615 cites W2028231353 @default.
- W4211246615 cites W2028700212 @default.
- W4211246615 cites W2031900710 @default.
- W4211246615 cites W2032430513 @default.
- W4211246615 cites W2034121285 @default.
- W4211246615 cites W2034544866 @default.
- W4211246615 cites W2036342654 @default.
- W4211246615 cites W2037504646 @default.
- W4211246615 cites W2038605297 @default.
- W4211246615 cites W2040687623 @default.
- W4211246615 cites W2040773927 @default.
- W4211246615 cites W2046719596 @default.
- W4211246615 cites W2047094545 @default.
- W4211246615 cites W2048723158 @default.
- W4211246615 cites W2049024956 @default.
- W4211246615 cites W2049626930 @default.
- W4211246615 cites W2056972905 @default.
- W4211246615 cites W2065846481 @default.
- W4211246615 cites W2066560589 @default.
- W4211246615 cites W2067312185 @default.
- W4211246615 cites W2067373519 @default.
- W4211246615 cites W2067601423 @default.
- W4211246615 cites W2070239849 @default.
- W4211246615 cites W2072513862 @default.
- W4211246615 cites W2073502897 @default.
- W4211246615 cites W2073546925 @default.
- W4211246615 cites W2077386452 @default.
- W4211246615 cites W2077955101 @default.