Matches in SemOpenAlex for { <https://semopenalex.org/work/W4211248224> ?p ?o ?g. }
- W4211248224 endingPage "H1191" @default.
- W4211248224 startingPage "H1179" @default.
- W4211248224 abstract "Optogenetics is an emerging technology for optical interrogation and control of biological function with high specificity and high spatiotemporal resolution. Mammalian cells and tissues can be sensitized to respond to light by a relatively simple and well-tolerated genetic modification using microbial opsins (light-gated ion channels and pumps). These can achieve fast and specific excitatory or inhibitory response, offering distinct advantages over traditional pharmacological or electrical means of perturbation. Since the first demonstrations of utility in mammalian cells (neurons) in 2005, optogenetics has spurred immense research activity and has inspired numerous applications for dissection of neural circuitry and understanding of brain function in health and disease, applications ranging from in vitro to work in behaving animals. Only recently (since 2010), the field has extended to cardiac applications with less than a dozen publications to date. In consideration of the early phase of work on cardiac optogenetics and the impact of the technique in understanding another excitable tissue, the brain, this review is largely a perspective of possibilities in the heart. It covers the basic principles of operation of light-sensitive ion channels and pumps, the available tools and ongoing efforts in optimizing them, overview of neuroscience use, as well as cardiac-specific questions of implementation and ideas for best use of this emerging technology in the heart." @default.
- W4211248224 created "2022-02-13" @default.
- W4211248224 creator A5048078446 @default.
- W4211248224 date "2013-05-01" @default.
- W4211248224 modified "2023-10-16" @default.
- W4211248224 title "Cardiac optogenetics" @default.
- W4211248224 cites W1534035894 @default.
- W4211248224 cites W1542263802 @default.
- W4211248224 cites W1543685213 @default.
- W4211248224 cites W1592611495 @default.
- W4211248224 cites W1644182666 @default.
- W4211248224 cites W1963937305 @default.
- W4211248224 cites W1964114016 @default.
- W4211248224 cites W1967712913 @default.
- W4211248224 cites W1969650326 @default.
- W4211248224 cites W1971797700 @default.
- W4211248224 cites W1971919681 @default.
- W4211248224 cites W1972183015 @default.
- W4211248224 cites W1978253480 @default.
- W4211248224 cites W1979421119 @default.
- W4211248224 cites W1981006926 @default.
- W4211248224 cites W1982277188 @default.
- W4211248224 cites W1983140929 @default.
- W4211248224 cites W1986892307 @default.
- W4211248224 cites W1988862252 @default.
- W4211248224 cites W1990867492 @default.
- W4211248224 cites W1992188171 @default.
- W4211248224 cites W1992506424 @default.
- W4211248224 cites W1993738260 @default.
- W4211248224 cites W1995454338 @default.
- W4211248224 cites W1996674530 @default.
- W4211248224 cites W1996744375 @default.
- W4211248224 cites W1997073648 @default.
- W4211248224 cites W1997529300 @default.
- W4211248224 cites W1998085200 @default.
- W4211248224 cites W1998607564 @default.
- W4211248224 cites W1998821319 @default.
- W4211248224 cites W2001406655 @default.
- W4211248224 cites W2007196303 @default.
- W4211248224 cites W2008758574 @default.
- W4211248224 cites W2009534332 @default.
- W4211248224 cites W2012271461 @default.
- W4211248224 cites W2015071110 @default.
- W4211248224 cites W2016706151 @default.
- W4211248224 cites W2021072126 @default.
- W4211248224 cites W2023230481 @default.
- W4211248224 cites W2023732600 @default.
- W4211248224 cites W2024305830 @default.
- W4211248224 cites W2025026601 @default.
- W4211248224 cites W2025081427 @default.
- W4211248224 cites W2026920679 @default.
- W4211248224 cites W2028173291 @default.
- W4211248224 cites W2032154466 @default.
- W4211248224 cites W2034064942 @default.
- W4211248224 cites W2036048932 @default.
- W4211248224 cites W2036962817 @default.
- W4211248224 cites W2037594700 @default.
- W4211248224 cites W2041199992 @default.
- W4211248224 cites W2043358402 @default.
- W4211248224 cites W2044697395 @default.
- W4211248224 cites W2045571228 @default.
- W4211248224 cites W2046514878 @default.
- W4211248224 cites W2046856562 @default.
- W4211248224 cites W2047822309 @default.
- W4211248224 cites W2049717499 @default.
- W4211248224 cites W2050932531 @default.
- W4211248224 cites W2051137660 @default.
- W4211248224 cites W2051682616 @default.
- W4211248224 cites W2053080874 @default.
- W4211248224 cites W2054939201 @default.
- W4211248224 cites W2056493740 @default.
- W4211248224 cites W2058488568 @default.
- W4211248224 cites W2059485600 @default.
- W4211248224 cites W2062021082 @default.
- W4211248224 cites W2062594525 @default.
- W4211248224 cites W2063210874 @default.
- W4211248224 cites W2065814524 @default.
- W4211248224 cites W2066914900 @default.
- W4211248224 cites W2068364567 @default.
- W4211248224 cites W2069294819 @default.
- W4211248224 cites W2069441590 @default.
- W4211248224 cites W2071619457 @default.
- W4211248224 cites W2072652550 @default.
- W4211248224 cites W2072739064 @default.
- W4211248224 cites W2073674965 @default.
- W4211248224 cites W2077100763 @default.
- W4211248224 cites W2079590230 @default.
- W4211248224 cites W2081784613 @default.
- W4211248224 cites W2083932518 @default.
- W4211248224 cites W2084390299 @default.
- W4211248224 cites W2084556601 @default.
- W4211248224 cites W2085493691 @default.
- W4211248224 cites W2085523626 @default.
- W4211248224 cites W2087927773 @default.
- W4211248224 cites W2088186055 @default.
- W4211248224 cites W2088342226 @default.
- W4211248224 cites W2088944569 @default.
- W4211248224 cites W2090654839 @default.