FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4211250912> ?p ?o ?g. }

• W4211250912 abstract "Tranexamic acid (TXA) has been shown to reduce blood loss significantly in shoulder arthroplasty. Oral TXA is significantly cheaper than intravenous TXA, but there has been no published literature comparing oral and intravenous TXA in shoulder arthroplasty. The purpose of this study was to compare the efficacy and safety of oral versus intravenous TXA in shoulder arthroplasty. We hypothesized that oral and intravenous TXA are equivalent at reducing blood loss following shoulder arthroplasty. This study was approved by the New Zealand Health and Disability Ethics Committee (HDEC) and registered with the Australian and New Zealand Clinical Trials Registry (ANZCTR). Patients undergoing elective shoulder arthroplasties were prospectively randomized into one of two groups. In the oral TXA group, 2g of TXA was administered two hours prior to induction of anesthesia, and in the intravenous TXA group, 1.5g of TXA was administered as a bolus following induction of anesthesia. The primary outcome was a reduction in hemoglobin concentration. The secondary outcomes included drain output, number of blood units transfused, length of hospital stay, and complications. A total of 80 consecutive patients were randomized. The baseline demographics were comparable between the two groups. There was no difference in the primary outcome measure or any of the secondary outcome measures. With regards to the primary outcome measure, using a two one-sided test (TOST) for equivalence, with a P value of < 0.05 demonstrating equivalence, the mean reduction of hemoglobin was 23.30g/L (± 1.62) versus 22.45g/L (± 1.30) for the oral and the intravenous groups, respectively ( P < .001). Postoperative drain output was 74.58mLs (± 11.27) versus 90.03mLs (± 14.53) for the oral and the intravenous groups, respectively ( P = .41). Furthermore, there was no difference in the number of blood units transfused, length of hospital stay, and complications. To the best of our knowledge, this is the first study in the literature comparing oral and intravenous tranexamic in shoulder arthroplasty, and we found no difference in the efficacy of the two routes of administration. Surgeons should be encouraged to use the less expensive oral form of the medication as a means to minimize overall healthcare expenditure." @default.
• W4211250912 created "2022-02-13" @default.
• W4211250912 creator A5000752718 @default.
• W4211250912 creator A5006380737 @default.
• W4211250912 creator A5034756258 @default.
• W4211250912 creator A5039100905 @default.
• W4211250912 creator A5042281911 @default.
• W4211250912 creator A5079553214 @default.
• W4211250912 creator A5091606761 @default.
• W4211250912 date "2022-02-01" @default.
• W4211250912 modified "2023-10-03" @default.
• W4211250912 title "Oral and Intravenous Tranexamic Acid Are Equivalent at Reducing Blood Loss Following Shoulder Arthroplasty - a multicentre, double-blinded, randomized, placebo-controlled trial" @default.
• W4211250912 cites W1995103763 @default.
• W4211250912 cites W2184190511 @default.
• W4211250912 cites W2300402380 @default.
• W4211250912 cites W2338880694 @default.
• W4211250912 cites W2508154305 @default.
• W4211250912 cites W2585904185 @default.
• W4211250912 cites W2592452759 @default.
• W4211250912 cites W2754682189 @default.
• W4211250912 cites W2764139256 @default.
• W4211250912 cites W2792000214 @default.
• W4211250912 cites W2793666044 @default.
• W4211250912 cites W2935936353 @default.
• W4211250912 cites W2941786713 @default.
• W4211250912 cites W3035080894 @default.
• W4211250912 cites W3119678630 @default.
• W4211250912 cites W3173871673 @default.
• W4211250912 doi "https://doi.org/10.1053/j.sart.2021.12.006" @default.
• W4211250912 hasPublicationYear "2022" @default.
• W4211250912 type Work @default.
• W4211250912 citedByCount "0" @default.
• W4211250912 crossrefType "journal-article" @default.
• W4211250912 hasAuthorship W4211250912A5000752718 @default.
• W4211250912 hasAuthorship W4211250912A5006380737 @default.
• W4211250912 hasAuthorship W4211250912A5034756258 @default.
• W4211250912 hasAuthorship W4211250912A5039100905 @default.
• W4211250912 hasAuthorship W4211250912A5042281911 @default.
• W4211250912 hasAuthorship W4211250912A5079553214 @default.
• W4211250912 hasAuthorship W4211250912A5091606761 @default.
• W4211250912 hasConcept C126322002 @default.
• W4211250912 hasConcept C141071460 @default.
• W4211250912 hasConcept C142724271 @default.
• W4211250912 hasConcept C168563851 @default.
• W4211250912 hasConcept C203092338 @default.
• W4211250912 hasConcept C204787440 @default.
• W4211250912 hasConcept C27081682 @default.
• W4211250912 hasConcept C2778336525 @default.
• W4211250912 hasConcept C2778917026 @default.
• W4211250912 hasConcept C2779637338 @default.
• W4211250912 hasConcept C2991743468 @default.
• W4211250912 hasConcept C42219234 @default.
• W4211250912 hasConcept C535046627 @default.
• W4211250912 hasConcept C71924100 @default.
• W4211250912 hasConceptScore W4211250912C126322002 @default.
• W4211250912 hasConceptScore W4211250912C141071460 @default.
• W4211250912 hasConceptScore W4211250912C142724271 @default.
• W4211250912 hasConceptScore W4211250912C168563851 @default.
• W4211250912 hasConceptScore W4211250912C203092338 @default.
• W4211250912 hasConceptScore W4211250912C204787440 @default.
• W4211250912 hasConceptScore W4211250912C27081682 @default.
• W4211250912 hasConceptScore W4211250912C2778336525 @default.
• W4211250912 hasConceptScore W4211250912C2778917026 @default.
• W4211250912 hasConceptScore W4211250912C2779637338 @default.
• W4211250912 hasConceptScore W4211250912C2991743468 @default.
• W4211250912 hasConceptScore W4211250912C42219234 @default.
• W4211250912 hasConceptScore W4211250912C535046627 @default.
• W4211250912 hasConceptScore W4211250912C71924100 @default.
• W4211250912 hasLocation W42112509121 @default.
• W4211250912 hasOpenAccess W4211250912 @default.
• W4211250912 hasPrimaryLocation W42112509121 @default.
• W4211250912 hasRelatedWork W1999291976 @default.
• W4211250912 hasRelatedWork W2116030324 @default.
• W4211250912 hasRelatedWork W2149682231 @default.
• W4211250912 hasRelatedWork W2160647648 @default.
• W4211250912 hasRelatedWork W2317612395 @default.
• W4211250912 hasRelatedWork W2406666456 @default.
• W4211250912 hasRelatedWork W3010381859 @default.
• W4211250912 hasRelatedWork W3182087953 @default.
• W4211250912 hasRelatedWork W4233116497 @default.
• W4211250912 hasRelatedWork W4233410146 @default.
• W4211250912 isParatext "false" @default.
• W4211250912 isRetracted "false" @default.
• W4211250912 workType "article" @default.