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- W4211256532 abstract "Therapeutics and diagnostics target key molecules that are characteristic to the biological pathways involved in various diseases and disorders. Antibodies are the most widely used molecular recognition tool in nature, thus, researchers have exploited antibodies to develop numerous drugs and diagnostics. However, the large size, complex structure, and modest stability of antibodies are suboptimal qualities for engineering. This workflow employs scaffold proteins (e.g., fibronectins and affibodies) as an alternative to antibodies, as their small size, simple structure, and relatively high tolerance to destabilizing mutations circumvent many of the shortcomings of antibodies." @default.
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- W4211256532 date "2022-02-01" @default.
- W4211256532 modified "2023-10-16" @default.
- W4211256532 title "Integration of protein engineering with machine learning to increase the efficiency of drug discovery" @default.
- W4211256532 doi "https://doi.org/10.1016/j.bpj.2021.11.2480" @default.
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