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- W4211256603 abstract "Background: Studies in hyperhidrosis have demonstrated that eccrine glands express all the signs of chronically activated normal glands but that the glands are otherwise morphologically normal. This study is the first to compare the morphology of normal and hyperhidrotic apocrine sweat glands. Methods: Apocrine sweat glands were isolated from the axilla of normal patients and hyperhidrotic individuals undergoing thoracic sypathectomy. Glands were wax embedded, sectioned (5 µm) and digital images analysed using analysis digital imaging software. All data are represented as mean ± s.e. from ≥30 observations. All tests of significance are Students t-test. Results: Hyperhidrotic glands were 30 per cent larger than normal in both length and width (length – normal 906 ± 71 µm versus 1173 ± 88 µm, P < 0.03: width – normal 613 ± 55 µm versus 811 ± 49 µm, P < 0.02). The tubule of the hyperhidrotic glands was significantly thicker (106.2 ± 2.6 µm versus 93.5 ± 4.9 µm; P < 0.03), whereas the hyperhidrotic lumen was 40 per cent wider than normal (56.6 ± 2.7 µm versus 40.6 ± 4.4 µm, P < 0.002). Excessive collagen matrix was excluded by measuring tubule area which was 60 per cent larger for hyperhidrotic glands compared to normal (257 575 ± 18 338 µm2versus 162 304 ± 12 971 µm2, P < 0.01) indicating that the hyperhidrotic glands were more tightly wound than normal. Conclusions: Apocrine sweat glands are not anatomically different in hyperhidrosis but are significantly larger, more coiled and have a larger luminal diameter. The cells also appear degranulated and more squamous suggesting increased activity. Hyperhidrosis is associated not only with increased eccrine activity but also affects apocine function." @default.
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- W4211256603 date "2002-01-01" @default.
- W4211256603 modified "2023-09-24" @default.
- W4211256603 title "Miscellaneous 03" @default.
- W4211256603 doi "https://doi.org/10.1046/j.1365-2168.89.s.1.24_3.x" @default.
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