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- W4211258900 endingPage "149" @default.
- W4211258900 startingPage "134" @default.
- W4211258900 abstract "Xenotransplantation using pigs as donors has major potential to address the donor organ supply, but also has significant challenges, the greatest of which is rejection of xenografts by the human antipig immune response. The xenoresponse differs significantly to the alloresponse because of the numerous molecular differences between pigs and humans, which stimulate greater involvement of innate immune mechanisms and alter the nature of the T-cell response. Furthermore, xenoimmunity is amplified by molecular incompatibilities that compromise the ability of key mechanisms to regulate coagulation and inflammation. One consequence of these differences is that the drugs developed to prevent allorejection are considerably less effective against xenorejection. It is now evident that long-term survival of most types of xenograft will depend on genetic modification of the donor, a strategy unique to xenotransplantation. Recent advances in this area, together with improved immunosuppressive regimens aimed at inducing tolerance, give cause for cautious optimism for the future of clinical xenotransplantation." @default.
- W4211258900 created "2022-02-13" @default.
- W4211258900 creator A5039238202 @default.
- W4211258900 creator A5067910050 @default.
- W4211258900 date "2014-07-25" @default.
- W4211258900 modified "2023-09-30" @default.
- W4211258900 title "Xenoimmunity" @default.
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