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• W4211260615 endingPage "136" @default.
• W4211260615 startingPage "105" @default.
• W4211260615 abstract "MicroRNAs (abbreviated: miRNAs) represent a class of small noncoding RNAs, first described in the nematode Caenorhabditis elegans. In 1993, the labs of Victor Ambros (Lee et al. 1993) and Gary Ruvkun (Wightman et al. 1993) discovered lin-4, the first member of the inexorably growing miRNA family of molecules, in close cooperation. Interestingly, it was not until the year 2000 that Reinhart and colleagues detected a second miRNA species – let-7 (Reinhart et al. 2000). The finding that the sequence of let-7 was conserved in a large variety of Metazoens from Drosophila to humans [in contrast to lin-4 which is exclusively expressed in Caenorhabditis; (Pasquinelli et al. 2000; Slack et al. 2000)] fueled miRNA research and revealed that this class of molecules is involved in the regulation of gene expression at a posttranscriptional level in presumably every multicellular organism. To date, almost 800 distinct miRNA species have been identified in the human genome [http://microrna.sanger.ac.uk/; (Griffiths-Jones et al. 2008)]. Those are estimated to regulate the expression of as much as 30% of all human transcripts (Lewis et al. 2005). MiRNAs are demonstrably involved in the physiological regulation of multiple cellular processes, such as proliferation, apoptosis, cell-cycle regulation, and differentiation (John et al. 2004; Johnson et al. 2005; Kiriakidou et al. 2004; Krek et al. 2005; Lee et al. 2005; Lim et al. 2005). As a consequence, abnormalities in miRNA activity were found to contribute to the pathogenesis and progression of various types of human cancers [reviewed in (Mirnezami et al. 2009; Visone and Croce 2009)], including malignant melanoma [reviewed in (Mueller and Bosserhoff 2009)]." @default.
• W4211260615 created "2022-02-13" @default.
• W4211260615 creator A5041627104 @default.
• W4211260615 creator A5053206032 @default.
• W4211260615 date "2011-01-01" @default.
• W4211260615 modified "2023-09-27" @default.
• W4211260615 title "miRNAs in Malignant Melanoma" @default.
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