FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4211262114> ?p ?o ?g. }

• W4211262114 abstract "Abstract Objective Polygenic scores (PGS) are widely used in psychiatric genetic associations studies due to their impressive power to predict focal outcomes. However, they lack in discriminatory power, in part due to the high degree of genetic overlap between psychiatric disorders. The lack of prediction specificity limits the clinical utility of psychiatric PGS, particularly for diagnostic applications. The goal of the study was to enhance the discriminatory power of psychiatric PGS for two highly comorbid and genetically correlated neurodevelopmental disorders in ADHD and autism spectrum disorder (ASD). Methods Genomic structural equation modeling (GenomicSEM) was used to generate novel PGS for ADHD and ASD by accounting for the genetic overlap between these disorders (and eight others) to achieve greater discriminatory power in non-focal outcome predictions. PGS associations were tested in two large independent samples – the Philadelphia Neurodevelopmental Cohort ( N =4,789) and the Simons Foundation Powering Autism Research for Knowledge (SPARK) ASD and sibling controls ( N =5,045) cohort. Results PGS from GenomicSEM achieved superior discriminatory power in terms of showing significantly attenuated associations with non-focal outcomes relative to traditionally computed PGS for these disorders. Additionally, genetic correlations between GenomicSEM PGS for ASD and ADHD were significantly attenuated in cross-trait associations with other psychiatric disorders and outcomes. Conclusions Psychiatric PGS associations are likely inflated by the high degree of genetic overlap between the psychiatric disorders. Methods such as GenomicSEM can be used to refine PGS signals to be more disorder-specific, thereby enhancing their discriminatory power for future diagnostic applications." @default.
• W4211262114 created "2022-02-13" @default.
• W4211262114 creator A5022731120 @default.
• W4211262114 creator A5026744055 @default.
• W4211262114 creator A5072181477 @default.
• W4211262114 creator A5083375749 @default.
• W4211262114 date "2022-02-10" @default.
• W4211262114 modified "2023-09-27" @default.
• W4211262114 title "Enhancing the Discriminatory Power of ADHD and Autism Spectrum Disorder Polygenic Scores in Clinical and Non-Clinical Samples" @default.
• W4211262114 cites W2030561475 @default.
• W4211262114 cites W2092706528 @default.
• W4211262114 cites W2104549677 @default.
• W4211262114 cites W2153860431 @default.
• W4211262114 cites W2161633633 @default.
• W4211262114 cites W2236290736 @default.
• W4211262114 cites W2592065003 @default.
• W4211262114 cites W2593395463 @default.
• W4211262114 cites W2599264051 @default.
• W4211262114 cites W2610359325 @default.
• W4211262114 cites W2739834351 @default.
• W4211262114 cites W2773146760 @default.
• W4211262114 cites W2785900161 @default.
• W4211262114 cites W2802815532 @default.
• W4211262114 cites W2911487850 @default.
• W4211262114 cites W2914482125 @default.
• W4211262114 cites W2917071648 @default.
• W4211262114 cites W2923203084 @default.
• W4211262114 cites W2932671560 @default.
• W4211262114 cites W2937611850 @default.
• W4211262114 cites W2946441043 @default.
• W4211262114 cites W2949479576 @default.
• W4211262114 cites W2950375827 @default.
• W4211262114 cites W2960372990 @default.
• W4211262114 cites W2963245083 @default.
• W4211262114 cites W2991850372 @default.
• W4211262114 cites W2995971356 @default.
• W4211262114 cites W3014593863 @default.
• W4211262114 cites W3087697844 @default.
• W4211262114 cites W3089119819 @default.
• W4211262114 cites W3101735287 @default.
• W4211262114 cites W3112076055 @default.
• W4211262114 cites W3124250451 @default.
• W4211262114 cites W3159656951 @default.
• W4211262114 cites W4247665917 @default.
• W4211262114 doi "https://doi.org/10.1101/2022.02.09.22270697" @default.
• W4211262114 hasPublicationYear "2022" @default.
• W4211262114 type Work @default.
• W4211262114 citedByCount "1" @default.
• W4211262114 countsByYear W42112621142023 @default.
• W4211262114 crossrefType "posted-content" @default.
• W4211262114 hasAuthorship W4211262114A5022731120 @default.
• W4211262114 hasAuthorship W4211262114A5026744055 @default.
• W4211262114 hasAuthorship W4211262114A5072181477 @default.
• W4211262114 hasAuthorship W4211262114A5083375749 @default.
• W4211262114 hasBestOaLocation W42112621141 @default.
• W4211262114 hasConcept C106934330 @default.
• W4211262114 hasConcept C118552586 @default.
• W4211262114 hasConcept C126322002 @default.
• W4211262114 hasConcept C138496976 @default.
• W4211262114 hasConcept C15744967 @default.
• W4211262114 hasConcept C199360897 @default.
• W4211262114 hasConcept C205778803 @default.
• W4211262114 hasConcept C2776194465 @default.
• W4211262114 hasConcept C2778538070 @default.
• W4211262114 hasConcept C2780783007 @default.
• W4211262114 hasConcept C41008148 @default.
• W4211262114 hasConcept C70410870 @default.
• W4211262114 hasConcept C71924100 @default.
• W4211262114 hasConcept C72563966 @default.
• W4211262114 hasConceptScore W4211262114C106934330 @default.
• W4211262114 hasConceptScore W4211262114C118552586 @default.
• W4211262114 hasConceptScore W4211262114C126322002 @default.
• W4211262114 hasConceptScore W4211262114C138496976 @default.
• W4211262114 hasConceptScore W4211262114C15744967 @default.
• W4211262114 hasConceptScore W4211262114C199360897 @default.
• W4211262114 hasConceptScore W4211262114C205778803 @default.
• W4211262114 hasConceptScore W4211262114C2776194465 @default.
• W4211262114 hasConceptScore W4211262114C2778538070 @default.
• W4211262114 hasConceptScore W4211262114C2780783007 @default.
• W4211262114 hasConceptScore W4211262114C41008148 @default.
• W4211262114 hasConceptScore W4211262114C70410870 @default.
• W4211262114 hasConceptScore W4211262114C71924100 @default.
• W4211262114 hasConceptScore W4211262114C72563966 @default.
• W4211262114 hasLocation W42112621141 @default.
• W4211262114 hasOpenAccess W4211262114 @default.
• W4211262114 hasPrimaryLocation W42112621141 @default.
• W4211262114 hasRelatedWork W2003533276 @default.
• W4211262114 hasRelatedWork W2056340971 @default.
• W4211262114 hasRelatedWork W2460229839 @default.
• W4211262114 hasRelatedWork W2460742235 @default.
• W4211262114 hasRelatedWork W2593972102 @default.
• W4211262114 hasRelatedWork W2765176855 @default.
• W4211262114 hasRelatedWork W2904856381 @default.
• W4211262114 hasRelatedWork W2912406012 @default.
• W4211262114 hasRelatedWork W2965367033 @default.
• W4211262114 hasRelatedWork W4224273885 @default.
• W4211262114 isParatext "false" @default.
• W4211262114 isRetracted "false" @default.
• W4211262114 workType "article" @default.