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- W4211262766 abstract "Heroin dependency has become a global problem and has caused significant clinical and socioeconomic burdens along with devastating medical consequences. Chronic drug exposure alters the expression and functional activity of 5-hydroxytryptamine (serotonin) 2A receptors (5-HT2ARs) in the brain. Furthermore, pharmacological blockade of 5-HT2ARs reduces cue-induced cocaine craving behaviors. In this study, we explored the influence of 5-HT2ARs on heroin-withdrawal behaviors in mice. Black C57BL/6J mice were given gradually increasing (10-50 mg/kg over 4.5 days) doses of heroin to induce heroin dependency, after which naloxone was given to precipitate withdrawal symptoms. MDL100907, a selective and potent 5-HT2AR antagonist, attenuated naloxone-precipitated withdrawal symptoms in these mice. In addition, 5-HT2AR protein levels increased significantly in the medial prefrontal cortex (mPFC), while phosphorylation of extracellular signal-regulated kinase (p-ERK) decreased in the mPFC after heroin exposure. In conclusion, these results suggest that 5-HT2ARs might be involved in the development of opioid dependency and that pharmacological blocking of 5-HT2ARs might be a new therapeutic strategy for heroin dependency." @default.
- W4211262766 created "2022-02-13" @default.
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- W4211262766 date "2022-02-09" @default.
- W4211262766 modified "2023-10-18" @default.
- W4211262766 title "Blockade of 5-Hydroxytryptamine 2A Receptor Attenuates Precipitation of Naloxone-Induced Withdrawal Symptoms in Opioid-Exposed Mice" @default.
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- W4211262766 cites W1972119507 @default.
- W4211262766 cites W1982026272 @default.
- W4211262766 cites W1999068689 @default.
- W4211262766 cites W2000827819 @default.
- W4211262766 cites W2003367821 @default.
- W4211262766 cites W2005949851 @default.
- W4211262766 cites W2007935614 @default.
- W4211262766 cites W2014776578 @default.
- W4211262766 cites W2016437478 @default.
- W4211262766 cites W2045060980 @default.
- W4211262766 cites W2052029379 @default.
- W4211262766 cites W2060324739 @default.
- W4211262766 cites W2063233463 @default.
- W4211262766 cites W2071815275 @default.
- W4211262766 cites W2073191271 @default.
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- W4211262766 cites W2078814818 @default.
- W4211262766 cites W2083771286 @default.
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- W4211262766 cites W2169863475 @default.
- W4211262766 cites W2327692652 @default.
- W4211262766 cites W2345112163 @default.
- W4211262766 cites W2395766503 @default.
- W4211262766 cites W2414860396 @default.
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- W4211262766 cites W2580419720 @default.
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- W4211262766 cites W2972309070 @default.
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- W4211262766 doi "https://doi.org/10.3389/fnbeh.2021.797217" @default.
- W4211262766 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35221941" @default.
- W4211262766 hasPublicationYear "2022" @default.
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