FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4211262802> ?p ?o ?g. }

• W4211262802 endingPage "1043" @default.
• W4211262802 startingPage "1035" @default.
• W4211262802 abstract "Objective: To evaluate the link between antidepressants and suicidal behavior and ideation (suicidality) in youth, adverse events from pediatric clinical trials were classified in order to identify suicidal events. The authors describe the Columbia Classification Algorithm for Suicide Assessment (C-CASA), a standardized suicidal rating system that provided data for the pediatric suicidal risk analysis of antidepressants conducted by the Food and Drug Administration (FDA). Method: Adverse events (N=427) from 25 pediatric antidepressant clinical trials were systematically identified by pharmaceutical companies. Randomly assigned adverse events were evaluated by three of nine independent expert suicidologists using the Columbia classification algorithm. Reliability of the C-CASA ratings and agreement with pharmaceutical company classification were estimated. Results: Twenty-six new, possibly suicidal events (behavior and ideation) that were not originally identified by pharmaceutical companies were identified in the C-CASA, and 12 events originally labeled as suicidal by pharmaceutical companies were eliminated, which resulted in a total of 38 discrepant ratings. For the specific label of “suicide attempt,” a relatively low level of agreement was observed between the C-CASA and pharmaceutical company ratings, with the C-CASA reporting a 50% reduction in ratings. Thus, although the C-CASA resulted in the identification of more suicidal events overall, fewer events were classified as suicide attempts. Additionally, the C-CASA ratings were highly reliable (intraclass correlation coefficient [ICC]=0.89). Conclusions: Utilizing a methodical, anchored approach to categorizing suicidality provides an accurate and comprehensive identification of suicidal events. The FDA’s audit of the C-CASA demonstrated excellent transportability of this approach. The Columbia algorithm was used to classify suicidal adverse events in the recent FDA adult antidepressant safety analyses and has also been mandated to be applied to all anticonvulsant trials and other centrally acting agents and nonpsychotropic drugs." @default.
• W4211262802 created "2022-02-13" @default.
• W4211262802 creator A5006420330 @default.
• W4211262802 creator A5033440527 @default.
• W4211262802 creator A5057457951 @default.
• W4211262802 creator A5062214025 @default.
• W4211262802 creator A5063767807 @default.
• W4211262802 date "2007-07-01" @default.
• W4211262802 modified "2023-10-18" @default.
• W4211262802 title "Columbia Classification Algorithm of Suicide Assessment (C-CASA): Classification of Suicidal Events in the FDA’s Pediatric Suicidal Risk Analysis of Antidepressants" @default.
• W4211262802 doi "https://doi.org/10.1176/ajp.2007.164.7.1035" @default.
• W4211262802 hasPublicationYear "2007" @default.
• W4211262802 type Work @default.
• W4211262802 citedByCount "521" @default.
• W4211262802 countsByYear W42112628022012 @default.
• W4211262802 countsByYear W42112628022013 @default.
• W4211262802 countsByYear W42112628022014 @default.
• W4211262802 countsByYear W42112628022015 @default.
• W4211262802 countsByYear W42112628022016 @default.
• W4211262802 countsByYear W42112628022017 @default.
• W4211262802 countsByYear W42112628022018 @default.
• W4211262802 countsByYear W42112628022019 @default.
• W4211262802 countsByYear W42112628022020 @default.
• W4211262802 countsByYear W42112628022021 @default.
• W4211262802 countsByYear W42112628022022 @default.
• W4211262802 countsByYear W42112628022023 @default.
• W4211262802 crossrefType "journal-article" @default.
• W4211262802 hasAuthorship W4211262802A5006420330 @default.
• W4211262802 hasAuthorship W4211262802A5033440527 @default.
• W4211262802 hasAuthorship W4211262802A5057457951 @default.
• W4211262802 hasAuthorship W4211262802A5062214025 @default.
• W4211262802 hasAuthorship W4211262802A5063767807 @default.
• W4211262802 hasConcept C118552586 @default.
• W4211262802 hasConcept C190385971 @default.
• W4211262802 hasConcept C2776641880 @default.
• W4211262802 hasConcept C2780842732 @default.
• W4211262802 hasConcept C3017944768 @default.
• W4211262802 hasConcept C526869908 @default.
• W4211262802 hasConcept C545542383 @default.
• W4211262802 hasConcept C71924100 @default.
• W4211262802 hasConceptScore W4211262802C118552586 @default.
• W4211262802 hasConceptScore W4211262802C190385971 @default.
• W4211262802 hasConceptScore W4211262802C2776641880 @default.
• W4211262802 hasConceptScore W4211262802C2780842732 @default.
• W4211262802 hasConceptScore W4211262802C3017944768 @default.
• W4211262802 hasConceptScore W4211262802C526869908 @default.
• W4211262802 hasConceptScore W4211262802C545542383 @default.
• W4211262802 hasConceptScore W4211262802C71924100 @default.
• W4211262802 hasIssue "7" @default.
• W4211262802 hasLocation W42112628021 @default.
• W4211262802 hasOpenAccess W4211262802 @default.
• W4211262802 hasPrimaryLocation W42112628021 @default.
• W4211262802 hasRelatedWork W1977630765 @default.
• W4211262802 hasRelatedWork W2068121488 @default.
• W4211262802 hasRelatedWork W2110475741 @default.
• W4211262802 hasRelatedWork W2152905232 @default.
• W4211262802 hasRelatedWork W2529681323 @default.
• W4211262802 hasRelatedWork W2537821271 @default.
• W4211262802 hasRelatedWork W2548962980 @default.
• W4211262802 hasRelatedWork W2884402283 @default.
• W4211262802 hasRelatedWork W2902237298 @default.
• W4211262802 hasRelatedWork W3094029734 @default.
• W4211262802 hasVolume "164" @default.
• W4211262802 isParatext "false" @default.
• W4211262802 isRetracted "false" @default.
• W4211262802 workType "article" @default.