Matches in SemOpenAlex for { <https://semopenalex.org/work/W4212768052> ?p ?o ?g. }
- W4212768052 abstract "Liquid-liquid phase separation (LLPS) is emerging as a major principle for the mesoscale organization of proteins, RNAs, and membrane-bound organelles into biomolecular condensates. These condensates allow for rapid cellular responses to changes in metabolic activities and signaling. Nowhere is this regulation more important than in neurons and glia, where cellular physiology occurs simultaneously on a range of time- and length-scales. In a number of neurodegenerative diseases, such as Amyotrophic Lateral Sclerosis (ALS), misregulation of biomolecular condensates leads to the formation of insoluble aggregates-a pathological hallmark of both sporadic and familial ALS. Here, we summarize how the emerging knowledge about the LLPS of ALS-related proteins corroborates with their aggregation. Understanding the mechanisms that lead to protein aggregation in ALS and how cells respond to these aggregates promises to open new directions for drug development." @default.
- W4212768052 created "2022-02-24" @default.
- W4212768052 creator A5024514830 @default.
- W4212768052 creator A5029043246 @default.
- W4212768052 creator A5041569809 @default.
- W4212768052 creator A5059633699 @default.
- W4212768052 creator A5065916712 @default.
- W4212768052 date "2022-02-17" @default.
- W4212768052 modified "2023-10-16" @default.
- W4212768052 title "Emerging Roles for Phase Separation of RNA-Binding Proteins in Cellular Pathology of ALS" @default.
- W4212768052 cites W1503916499 @default.
- W4212768052 cites W1520519126 @default.
- W4212768052 cites W1585921029 @default.
- W4212768052 cites W1619082318 @default.
- W4212768052 cites W1854281301 @default.
- W4212768052 cites W1952608303 @default.
- W4212768052 cites W1963646113 @default.
- W4212768052 cites W1965286266 @default.
- W4212768052 cites W1968726059 @default.
- W4212768052 cites W1977399503 @default.
- W4212768052 cites W1983070191 @default.
- W4212768052 cites W1985681646 @default.
- W4212768052 cites W1986199992 @default.
- W4212768052 cites W1987426179 @default.
- W4212768052 cites W1988236141 @default.
- W4212768052 cites W1991570014 @default.
- W4212768052 cites W1991660507 @default.
- W4212768052 cites W1993084790 @default.
- W4212768052 cites W1994524751 @default.
- W4212768052 cites W1995657253 @default.
- W4212768052 cites W2003618511 @default.
- W4212768052 cites W2004850573 @default.
- W4212768052 cites W2007400675 @default.
- W4212768052 cites W2008092626 @default.
- W4212768052 cites W2012935774 @default.
- W4212768052 cites W2015064721 @default.
- W4212768052 cites W2016107719 @default.
- W4212768052 cites W2016332933 @default.
- W4212768052 cites W2020159880 @default.
- W4212768052 cites W2022884507 @default.
- W4212768052 cites W2031964319 @default.
- W4212768052 cites W2036379239 @default.
- W4212768052 cites W2041451000 @default.
- W4212768052 cites W2042930414 @default.
- W4212768052 cites W2044821390 @default.
- W4212768052 cites W2051470096 @default.
- W4212768052 cites W2052888134 @default.
- W4212768052 cites W2053362200 @default.
- W4212768052 cites W2054077521 @default.
- W4212768052 cites W2056401645 @default.
- W4212768052 cites W2059431762 @default.
- W4212768052 cites W2065139981 @default.
- W4212768052 cites W2066107559 @default.
- W4212768052 cites W2069045437 @default.
- W4212768052 cites W2070085869 @default.
- W4212768052 cites W2073974761 @default.
- W4212768052 cites W2074726646 @default.
- W4212768052 cites W2075186362 @default.
- W4212768052 cites W2082157398 @default.
- W4212768052 cites W2082210819 @default.
- W4212768052 cites W2086896046 @default.
- W4212768052 cites W2088204428 @default.
- W4212768052 cites W2090926709 @default.
- W4212768052 cites W2092082741 @default.
- W4212768052 cites W2096386031 @default.
- W4212768052 cites W2100181935 @default.
- W4212768052 cites W2102898524 @default.
- W4212768052 cites W2104160257 @default.
- W4212768052 cites W2107754763 @default.
- W4212768052 cites W2108663777 @default.
- W4212768052 cites W2109302593 @default.
- W4212768052 cites W2110803302 @default.
- W4212768052 cites W2111796925 @default.
- W4212768052 cites W2113792524 @default.
- W4212768052 cites W2117428493 @default.
- W4212768052 cites W2118839997 @default.
- W4212768052 cites W2120156669 @default.
- W4212768052 cites W2120469195 @default.
- W4212768052 cites W2123437304 @default.
- W4212768052 cites W2127861463 @default.
- W4212768052 cites W2127899638 @default.
- W4212768052 cites W2131321387 @default.
- W4212768052 cites W2133081366 @default.
- W4212768052 cites W2133318565 @default.
- W4212768052 cites W2134408741 @default.
- W4212768052 cites W2135607950 @default.
- W4212768052 cites W2136448211 @default.
- W4212768052 cites W2141231623 @default.
- W4212768052 cites W2142269238 @default.
- W4212768052 cites W2143069387 @default.
- W4212768052 cites W2147802916 @default.
- W4212768052 cites W2149122401 @default.
- W4212768052 cites W2149918626 @default.
- W4212768052 cites W2150430904 @default.
- W4212768052 cites W2150860983 @default.
- W4212768052 cites W2153410398 @default.
- W4212768052 cites W2157150055 @default.
- W4212768052 cites W2157252269 @default.
- W4212768052 cites W2159354359 @default.
- W4212768052 cites W2159556459 @default.