Matches in SemOpenAlex for { <https://semopenalex.org/work/W4212781155> ?p ?o ?g. }
- W4212781155 endingPage "671" @default.
- W4212781155 startingPage "671" @default.
- W4212781155 abstract "Glucocorticoids (GCs) are effective anti-inflammatory drugs, but their clinical use is limited by their side effects. Using liposomes to target GCs to inflammatory sites is a promising approach to improve their therapeutic ratio. We used zebrafish embryos to visualize the biodistribution of liposomes and to determine the anti-inflammatory and adverse effects of the GC prednisolone phosphate (PLP) encapsulated in these liposomes. Our results showed that PEGylated liposomes remained in circulation for long periods of time, whereas a novel type of liposomes (which we named AmbiMACs) selectively targeted macrophages. Upon laser wounding of the tail, both types of liposomes were shown to accumulate near the wounding site. Encapsulation of PLP in the PEGylated liposomes and AmbiMACs increased its potency to inhibit the inflammatory response. However, encapsulation of PLP in either type of liposome reduced its inhibitory effect on tissue regeneration, and encapsulation in PEGylated liposomes attenuated the activation of glucocorticoid-responsive gene expression throughout the body. Thus, by exploiting the unique possibilities of the zebrafish animal model to study the biodistribution as well as the anti-inflammatory and adverse effects of liposomal formulations of PLP, we showed that PEGylated liposomes and AmbiMACs increase the therapeutic ratio of this GC drug." @default.
- W4212781155 created "2022-02-24" @default.
- W4212781155 creator A5011398750 @default.
- W4212781155 creator A5012597588 @default.
- W4212781155 creator A5014848900 @default.
- W4212781155 creator A5021621469 @default.
- W4212781155 creator A5022892166 @default.
- W4212781155 creator A5082191409 @default.
- W4212781155 creator A5089364752 @default.
- W4212781155 date "2022-02-15" @default.
- W4212781155 modified "2023-09-26" @default.
- W4212781155 title "Two Types of Liposomal Formulations Improve the Therapeutic Ratio of Prednisolone Phosphate in a Zebrafish Model for Inflammation" @default.
- W4212781155 cites W1151614859 @default.
- W4212781155 cites W1585705786 @default.
- W4212781155 cites W1605768991 @default.
- W4212781155 cites W1975775640 @default.
- W4212781155 cites W1977615011 @default.
- W4212781155 cites W1979720326 @default.
- W4212781155 cites W1981239255 @default.
- W4212781155 cites W1984439372 @default.
- W4212781155 cites W1993977844 @default.
- W4212781155 cites W1998020561 @default.
- W4212781155 cites W2002223683 @default.
- W4212781155 cites W2020179710 @default.
- W4212781155 cites W2030094610 @default.
- W4212781155 cites W2039675935 @default.
- W4212781155 cites W2044571134 @default.
- W4212781155 cites W2050195517 @default.
- W4212781155 cites W2050480410 @default.
- W4212781155 cites W2059422902 @default.
- W4212781155 cites W2063838991 @default.
- W4212781155 cites W2064137717 @default.
- W4212781155 cites W2070003597 @default.
- W4212781155 cites W2072812592 @default.
- W4212781155 cites W2076489036 @default.
- W4212781155 cites W2077129199 @default.
- W4212781155 cites W2080041249 @default.
- W4212781155 cites W2082340694 @default.
- W4212781155 cites W2088062002 @default.
- W4212781155 cites W2089248014 @default.
- W4212781155 cites W2095686912 @default.
- W4212781155 cites W2098047948 @default.
- W4212781155 cites W2111357501 @default.
- W4212781155 cites W2117634037 @default.
- W4212781155 cites W2119390272 @default.
- W4212781155 cites W2121113871 @default.
- W4212781155 cites W2121469147 @default.
- W4212781155 cites W2145334570 @default.
- W4212781155 cites W2150824761 @default.
- W4212781155 cites W2154074059 @default.
- W4212781155 cites W2159493805 @default.
- W4212781155 cites W2165207036 @default.
- W4212781155 cites W2169222334 @default.
- W4212781155 cites W2299393419 @default.
- W4212781155 cites W2322473086 @default.
- W4212781155 cites W2406124884 @default.
- W4212781155 cites W2516694652 @default.
- W4212781155 cites W2545282995 @default.
- W4212781155 cites W2557975383 @default.
- W4212781155 cites W2588616120 @default.
- W4212781155 cites W2607399596 @default.
- W4212781155 cites W2734609532 @default.
- W4212781155 cites W2743154979 @default.
- W4212781155 cites W2746501329 @default.
- W4212781155 cites W2783978729 @default.
- W4212781155 cites W2789724794 @default.
- W4212781155 cites W2905111812 @default.
- W4212781155 cites W2907368812 @default.
- W4212781155 cites W2908883433 @default.
- W4212781155 cites W2909226523 @default.
- W4212781155 cites W2934840949 @default.
- W4212781155 cites W2950547863 @default.
- W4212781155 cites W2952679984 @default.
- W4212781155 cites W3002993580 @default.
- W4212781155 cites W3005634218 @default.
- W4212781155 cites W3023369726 @default.
- W4212781155 cites W3043594036 @default.
- W4212781155 cites W3083698728 @default.
- W4212781155 cites W3109746568 @default.
- W4212781155 cites W3151371597 @default.
- W4212781155 cites W3195903565 @default.
- W4212781155 cites W4211079954 @default.
- W4212781155 doi "https://doi.org/10.3390/cells11040671" @default.
- W4212781155 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35203318" @default.
- W4212781155 hasPublicationYear "2022" @default.
- W4212781155 type Work @default.
- W4212781155 citedByCount "2" @default.
- W4212781155 countsByYear W42127811552022 @default.
- W4212781155 crossrefType "journal-article" @default.
- W4212781155 hasAuthorship W4212781155A5011398750 @default.
- W4212781155 hasAuthorship W4212781155A5012597588 @default.
- W4212781155 hasAuthorship W4212781155A5014848900 @default.
- W4212781155 hasAuthorship W4212781155A5021621469 @default.
- W4212781155 hasAuthorship W4212781155A5022892166 @default.
- W4212781155 hasAuthorship W4212781155A5082191409 @default.
- W4212781155 hasAuthorship W4212781155A5089364752 @default.
- W4212781155 hasBestOaLocation W42127811551 @default.
- W4212781155 hasConcept C126322002 @default.