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- W4212786282 abstract "Background Traumatic brain injury (TBI) is a common clinical condition caused by external force. Aquaporin-4 (AQP4) in astrocytes participates in the generation of cell swelling in TBI.Methods This research explored the effect of AQP4 gene silencing in a TBI rat model. A hydraulic craniocerebral trauma instrument was employed for establishing the TBI rat model. AQP4 expression in the brain was inhibited by the injection of AQP4 shRNA-lentiviral vector. The expression of relative genes was evaluated by Western blot and qRT-PCR. Neuronal apoptosis was analyzed by TUNEL assay.Results AQP4 shRNA treatment inhibited AQP4 expression in the brain of rats with TBI. AQP4 shRNA alleviated TBI-induced brain edema and neurological deficit in rats. Neuronal apoptosis and astrocyte activation in TBI rats were reduced by AQP4 silencing.Conclusion This research demonstrated that AQP4 shRNA-induced silencing of AQP4 in the TBI rat model reduced the expression of AQP4 and GFAP, alleviated brain edema, neurological deficit, neuronal apoptosis and inhibited astrocyte activation." @default.
- W4212786282 created "2022-02-24" @default.
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- W4212786282 date "2022-02-21" @default.
- W4212786282 modified "2023-09-27" @default.
- W4212786282 title "Neuroprotective effects of lentivirus‐mediated aquaporin‐4 gene silencing in rat model of traumatic brain injury" @default.
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- W4212786282 doi "https://doi.org/10.1080/01616412.2022.2039509" @default.
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