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- W4212794329 abstract "This project aims to first investigate the public awareness and understanding of the benefits and (health) risks of nanomaterials, whilst identifying the human exposure levels at typical engineered nanomaterials manufacturing industries. Next, the potential adverse biological impacts of carbon-based nanomaterials in vitro will be assessed in immune-relevant cell models, before, subsequently, at equivalent in vitro concentrations of occupational exposure scenarios. A specifically designed questionnaire indicated that individuals with a higher educational background had a better understanding of ‘nano’, however religious individuals generally had lower knowledge of the area. Air monitoring at typical carbon-based nanomaterials manufacturing facilities was carried out with DiSCmini and P-Trak particle counters, and a Flow air quality monitor over 12 months. Average particle concentrations in the manufacturing areas were <1,000-12,000pt/cm3 at the carbon-based nanomaterials manufacturing facilities, and nanomaterial processing activities increased aerosol concentrations. PMA differentiated THP-1 (dTHP-1) cells and primary human blood monocyte-derived macrophages were compared for their sensitivity in elucidating the immunological, cytotoxic and morphological impacts of three different surface-modified graphene nanomaterials at 2, 4, 8, 10, 20, 50 & 100μg/ml. Viability (Trypan blue exclusion) was reduced to 45-75%, and macrophage differentiation (expression of CD14) was increased 2-10x, as well as secretion of pro-inflammatory cytokines for both cell types. The NH2-graphene was observed to have the greatest impact in dTHP-1, and COOH-graphene in primary cells. At the in vitro equivalent human exposure levels (0.288, 2.879, 14.394, 43.182μg/ml), carbon nanotubes were more cytotoxic than the other engineered nanomaterials (graphene & carbon black), however the cytotoxic and immunological (CD86 expression) impact was low for each nanomaterial type. In conclusion this project demonstrated that occupational exposure levels differ within the carbon-based nanomaterials manufacturing industry, and although the public are aware of the potential health risks, the biological impacts of engineered nanomaterials, as tested in this study, show limited hazard at occupationally relevant doses." @default.
- W4212794329 created "2022-02-24" @default.
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- W4212794329 date "2022-02-09" @default.
- W4212794329 modified "2023-09-27" @default.
- W4212794329 title "Understanding the Human Health Impacts of Carbon-Based Nanomaterials Under Occupational Exposure Scenarios" @default.
- W4212794329 doi "https://doi.org/10.23889/suthesis.59337" @default.
- W4212794329 hasPublicationYear "2022" @default.
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