FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4212802354> ?p ?o ?g. }

• W4212802354 abstract "Neural tissue is a hierarchical multiscale system with intracellular and extracellular diffusion compartments at different length scales. The normal diffusion of bulk water in tissues is not able to detect the specific features of a complex system, providing nonlocal, diffusion measurement averaged on a 10-20 μm length scale. Being able to probe tissues with sub-micrometric diffusion length and quantify new local parameters, transient anomalous diffusion (tAD) would dramatically increase the diagnostic potential of diffusion MRI (DMRI) in detecting collective and sub-micro architectural changes of human tissues due to pathological damage. In DMRI, the use of tAD parameters quantified using specific DMRI acquisition protocols and their interpretation has often aroused skepticism. Although the derived formulas may accurately fit experimental diffusion-weighted data, the relationships between the postulated dynamical feature and the underlying geometrical structure remains elusive, or at most only suggestive. This work aimed to elucidate and validate the image contrast and information that can be obtained using the tAD model in white matter (WM) through a direct comparison between different diffusion metrics and histology. Towards this goal, we compared tAD metrics extracted from pure subdiffusion (α-imaging) and super-pseudodiffusion (γ-imaging) in excised mouse spinal cord WM, together with T2 and T2* relaxometry, conventional (normal diffusion-based) diffusion tensor imaging (DTI) and q-space imaging (QSI), with morphologic measures obtained by optical microscopy, to determine which structural and topological characteristics of myelinated axons influenced tAD contrast. Axon diameter (AxDiam), the standard deviation of diameters (SD ax.diam ), axonal density (AxDens) and effective local density (ELD) were extracted from optical images in several WM tracts. Among all the diffusion parameters obtained at 9.4 T, γ-metrics confirmed a strong dependence on magnetic in-homogeneities quantified by R2* = 1/T2* and showed the strongest associations with AxDiam and ELD. On the other hand, α-metrics showed strong associations with SD ax.diam and was significantly related to AxDens, suggesting its ability to quantify local heterogeneity degree in neural tissue. These results elucidate the biophysical mechanism underpinning tAD parameters and show the clinical potential of tAD-imaging, considering that both physiologic and pathologic neurodegeneration translate into alterations of WM morphometry and topology." @default.
• W4212802354 created "2022-02-24" @default.
• W4212802354 creator A5005327102 @default.
• W4212802354 creator A5007452991 @default.
• W4212802354 creator A5009569249 @default.
• W4212802354 creator A5034257119 @default.
• W4212802354 creator A5048558424 @default.
• W4212802354 creator A5072918418 @default.
• W4212802354 creator A5087804284 @default.
• W4212802354 date "2022-02-15" @default.
• W4212802354 modified "2023-09-27" @default.
• W4212802354 title "Transient Anomalous Diffusion MRI in Excised Mouse Spinal Cord: Comparison Among Different Diffusion Metrics and Validation With Histology" @default.
• W4212802354 cites W1544141338 @default.
• W4212802354 cites W1551506184 @default.
• W4212802354 cites W1583185485 @default.
• W4212802354 cites W1636787203 @default.
• W4212802354 cites W1944195060 @default.
• W4212802354 cites W1968127311 @default.
• W4212802354 cites W1970713332 @default.
• W4212802354 cites W1991515822 @default.
• W4212802354 cites W1998904894 @default.
• W4212802354 cites W2001509015 @default.
• W4212802354 cites W2004442072 @default.
• W4212802354 cites W2016533177 @default.
• W4212802354 cites W2017136064 @default.
• W4212802354 cites W2018259456 @default.
• W4212802354 cites W2020204431 @default.
• W4212802354 cites W2021882008 @default.
• W4212802354 cites W2026812901 @default.
• W4212802354 cites W2036194289 @default.
• W4212802354 cites W2041559462 @default.
• W4212802354 cites W2041765815 @default.
• W4212802354 cites W2046763552 @default.
• W4212802354 cites W2048041195 @default.
• W4212802354 cites W2058258445 @default.
• W4212802354 cites W2063093669 @default.
• W4212802354 cites W2064048266 @default.
• W4212802354 cites W2068286370 @default.
• W4212802354 cites W2079698575 @default.
• W4212802354 cites W2086209802 @default.
• W4212802354 cites W2090827852 @default.
• W4212802354 cites W2100509843 @default.
• W4212802354 cites W2105034852 @default.
• W4212802354 cites W2106495485 @default.
• W4212802354 cites W2111271983 @default.
• W4212802354 cites W2113464001 @default.
• W4212802354 cites W2120792389 @default.
• W4212802354 cites W2120862100 @default.
• W4212802354 cites W2122992893 @default.
• W4212802354 cites W2147688960 @default.
• W4212802354 cites W2148983475 @default.
• W4212802354 cites W2149337534 @default.
• W4212802354 cites W2156543869 @default.
• W4212802354 cites W2162960527 @default.
• W4212802354 cites W2264152830 @default.
• W4212802354 cites W2313159301 @default.
• W4212802354 cites W2342170199 @default.
• W4212802354 cites W2409837535 @default.
• W4212802354 cites W2467800314 @default.
• W4212802354 cites W2478162388 @default.
• W4212802354 cites W2508419374 @default.
• W4212802354 cites W2508982726 @default.
• W4212802354 cites W2530487116 @default.
• W4212802354 cites W2565435445 @default.
• W4212802354 cites W2743917928 @default.
• W4212802354 cites W2747366609 @default.
• W4212802354 cites W2757341748 @default.
• W4212802354 cites W2768271247 @default.
• W4212802354 cites W2794518469 @default.
• W4212802354 cites W2813591387 @default.
• W4212802354 cites W2905880506 @default.
• W4212802354 cites W2912762199 @default.
• W4212802354 cites W2962681100 @default.
• W4212802354 cites W2964012060 @default.
• W4212802354 cites W2967400625 @default.
• W4212802354 cites W2999619964 @default.
• W4212802354 cites W3016456328 @default.
• W4212802354 cites W3081907146 @default.
• W4212802354 cites W3088122550 @default.
• W4212802354 cites W3100936231 @default.
• W4212802354 cites W3101064457 @default.
• W4212802354 cites W3168066633 @default.
• W4212802354 doi "https://doi.org/10.3389/fnins.2021.797642" @default.
• W4212802354 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35242002" @default.
• W4212802354 hasPublicationYear "2022" @default.
• W4212802354 type Work @default.
• W4212802354 citedByCount "3" @default.
• W4212802354 countsByYear W42128023542022 @default.
• W4212802354 countsByYear W42128023542023 @default.
• W4212802354 crossrefType "journal-article" @default.
• W4212802354 hasAuthorship W4212802354A5005327102 @default.
• W4212802354 hasAuthorship W4212802354A5007452991 @default.
• W4212802354 hasAuthorship W4212802354A5009569249 @default.
• W4212802354 hasAuthorship W4212802354A5034257119 @default.
• W4212802354 hasAuthorship W4212802354A5048558424 @default.
• W4212802354 hasAuthorship W4212802354A5072918418 @default.
• W4212802354 hasAuthorship W4212802354A5087804284 @default.
• W4212802354 hasBestOaLocation W42128023541 @default.
• W4212802354 hasConcept C121332964 @default.
• W4212802354 hasConcept C126838900 @default.

• next