FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4212809095> ?p ?o ?g. }

• W4212809095 endingPage "101465" @default.
• W4212809095 startingPage "101465" @default.
• W4212809095 abstract "Bone morphogenetic protein 8B (BMP8B) plays a major role in the regulation of energy homeostasis by modulating brown adipose tissue (BAT) thermogenesis and white adipose tissue (WAT) browning. Here, we investigated whether BMP8B's role in metabolism is affected by obesity and the possible molecular mechanisms underlying that action.Central treatments with BMP8B were performed in rats fed a standard (SD) and high-fat diet (HFD), as well as in genetically modified mice. Energy balance studies, infrared thermographic analysis of BAT and molecular analysis of the hypothalamus, BAT and WAT were carried out.We show for the first time that HFD-induced obesity elicits resistance to the central actions of BMP8B on energy balance. This obesity-induced BMP8B resistance is explained by i) lack of effects on AMP-activated protein kinase (AMPK) signaling, ii) decreased BMP receptors signaling and iii) reduced expression of Bardet-Biedl Syndrome 1 (BBS1) protein, a key component of the protein complex BBSome in the ventromedial nucleus of the hypothalamus (VMH). The possible mechanistic involvement of BBS1 in this process is demonstrated by lack of a central response to BMP8B in mice carrying a single missense disease-causing mutation in the Bbs1 gene.Overall, our data uncover a new mechanism of central resistance to hormonal action that may be of relevance in the pathophysiology of obesity." @default.
• W4212809095 created "2022-02-24" @default.
• W4212809095 creator A5005362009 @default.
• W4212809095 creator A5005941549 @default.
• W4212809095 creator A5007805428 @default.
• W4212809095 creator A5009842537 @default.
• W4212809095 creator A5020982137 @default.
• W4212809095 creator A5028809564 @default.
• W4212809095 creator A5044168126 @default.
• W4212809095 creator A5044402909 @default.
• W4212809095 creator A5051902439 @default.
• W4212809095 creator A5073274008 @default.
• W4212809095 creator A5090089030 @default.
• W4212809095 date "2022-05-01" @default.
• W4212809095 modified "2023-10-03" @default.
• W4212809095 title "Obesity induces resistance to central action of BMP8B through a mechanism involving the BBSome" @default.
• W4212809095 cites W1044297626 @default.
• W4212809095 cites W1509405108 @default.
• W4212809095 cites W1963857091 @default.
• W4212809095 cites W2042621509 @default.
• W4212809095 cites W2070582535 @default.
• W4212809095 cites W2077033935 @default.
• W4212809095 cites W2081573872 @default.
• W4212809095 cites W2087017560 @default.
• W4212809095 cites W2091795452 @default.
• W4212809095 cites W2091988898 @default.
• W4212809095 cites W2096190491 @default.
• W4212809095 cites W2100538674 @default.
• W4212809095 cites W2134944069 @default.
• W4212809095 cites W2138572940 @default.
• W4212809095 cites W2159444491 @default.
• W4212809095 cites W2164577763 @default.
• W4212809095 cites W2164600485 @default.
• W4212809095 cites W2290479358 @default.
• W4212809095 cites W2369258731 @default.
• W4212809095 cites W2402553346 @default.
• W4212809095 cites W2515318044 @default.
• W4212809095 cites W2518904228 @default.
• W4212809095 cites W2519369640 @default.
• W4212809095 cites W2558408965 @default.
• W4212809095 cites W2590097571 @default.
• W4212809095 cites W2611135576 @default.
• W4212809095 cites W2727251727 @default.
• W4212809095 cites W2885871973 @default.
• W4212809095 cites W2886277721 @default.
• W4212809095 cites W2897455519 @default.
• W4212809095 cites W2900761438 @default.
• W4212809095 cites W2945687901 @default.
• W4212809095 cites W2966964832 @default.
• W4212809095 cites W2967123345 @default.
• W4212809095 cites W2971711445 @default.
• W4212809095 cites W3011359459 @default.
• W4212809095 cites W3023022662 @default.
• W4212809095 cites W3027189358 @default.
• W4212809095 cites W3033065537 @default.
• W4212809095 cites W3136988226 @default.
• W4212809095 cites W3171439164 @default.
• W4212809095 cites W3183683902 @default.
• W4212809095 cites W3188400578 @default.
• W4212809095 cites W3194196501 @default.
• W4212809095 cites W3196933545 @default.
• W4212809095 cites W3207377400 @default.
• W4212809095 doi "https://doi.org/10.1016/j.molmet.2022.101465" @default.
• W4212809095 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35218946" @default.
• W4212809095 hasPublicationYear "2022" @default.
• W4212809095 type Work @default.
• W4212809095 citedByCount "2" @default.
• W4212809095 countsByYear W42128090952022 @default.
• W4212809095 crossrefType "journal-article" @default.
• W4212809095 hasAuthorship W4212809095A5005362009 @default.
• W4212809095 hasAuthorship W4212809095A5005941549 @default.
• W4212809095 hasAuthorship W4212809095A5007805428 @default.
• W4212809095 hasAuthorship W4212809095A5009842537 @default.
• W4212809095 hasAuthorship W4212809095A5020982137 @default.
• W4212809095 hasAuthorship W4212809095A5028809564 @default.
• W4212809095 hasAuthorship W4212809095A5044168126 @default.
• W4212809095 hasAuthorship W4212809095A5044402909 @default.
• W4212809095 hasAuthorship W4212809095A5051902439 @default.
• W4212809095 hasAuthorship W4212809095A5073274008 @default.
• W4212809095 hasAuthorship W4212809095A5090089030 @default.
• W4212809095 hasBestOaLocation W42128090951 @default.
• W4212809095 hasConcept C11960822 @default.
• W4212809095 hasConcept C126322002 @default.
• W4212809095 hasConcept C134018914 @default.
• W4212809095 hasConcept C151279926 @default.
• W4212809095 hasConcept C151955695 @default.
• W4212809095 hasConcept C171089720 @default.
• W4212809095 hasConcept C2491326 @default.
• W4212809095 hasConcept C2780124434 @default.
• W4212809095 hasConcept C2780642333 @default.
• W4212809095 hasConcept C511355011 @default.
• W4212809095 hasConcept C71924100 @default.
• W4212809095 hasConcept C86803240 @default.
• W4212809095 hasConcept C95444343 @default.
• W4212809095 hasConcept C97029542 @default.
• W4212809095 hasConceptScore W4212809095C11960822 @default.
• W4212809095 hasConceptScore W4212809095C126322002 @default.
• W4212809095 hasConceptScore W4212809095C134018914 @default.

• next