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- W4212810908 abstract "Non-alcoholic fatty liver disease (NAFLD) prevalence has increased drastically in recent decades, affecting up to 25% of the world's population. NAFLD is a spectrum of different diseases that starts with asymptomatic steatosis and continues with development of an inflammatory response called steatohepatitis, which can progress to fibrosis. Several molecular and metabolic changes are required for the hepatocyte to finally vary its function; hence a multiple hit hypothesis seems a more accurate proposal. Previous studies and current knowledge suggest that in most cases, NAFLD initiates and progresses through most of nine hallmarks of the disease, although the triggers and mechanisms for these can vary widely. The use of animal models remains crucial for understanding the disease and for developing tools based on biological knowledge. Among certain requirements to be met, a good model must imitate certain aspects of the human NAFLD disorder, be reliable and reproducible, have low mortality, and be compatible with a simple and feasible method. Metabolism studies in these models provides a direct reflection of the workings of the cell and may be a useful approach to better understand the initiation and progression of the disease. Metabolomics seems a valid tool for studying metabolic pathways and crosstalk between organs affected in animal models of NAFLD and for the discovery and validation of relevant biomarkers with biological understanding. In this review, we provide a brief introduction to NAFLD hallmarks, the five groups of animal models available for studying NAFLD and the potential role of metabolomics in the study of experimental NAFLD." @default.
- W4212810908 created "2022-02-24" @default.
- W4212810908 creator A5005374634 @default.
- W4212810908 creator A5073089096 @default.
- W4212810908 creator A5086861413 @default.
- W4212810908 date "2022-02-27" @default.
- W4212810908 modified "2023-10-18" @default.
- W4212810908 title "Rodent models and metabolomics in non-alcoholic fatty liver disease: What can we learn?" @default.
- W4212810908 cites W1510203407 @default.
- W4212810908 cites W1606133142 @default.
- W4212810908 cites W1964562779 @default.
- W4212810908 cites W1969807612 @default.
- W4212810908 cites W1972614642 @default.
- W4212810908 cites W1981333258 @default.
- W4212810908 cites W1982703569 @default.
- W4212810908 cites W1983720958 @default.
- W4212810908 cites W1987412129 @default.
- W4212810908 cites W1998471253 @default.
- W4212810908 cites W2003517551 @default.
- W4212810908 cites W2014718725 @default.
- W4212810908 cites W2029731735 @default.
- W4212810908 cites W2035970641 @default.
- W4212810908 cites W2041586213 @default.
- W4212810908 cites W2043998466 @default.
- W4212810908 cites W2053330602 @default.
- W4212810908 cites W2060249131 @default.
- W4212810908 cites W2079305124 @default.
- W4212810908 cites W2088433407 @default.
- W4212810908 cites W2089264179 @default.
- W4212810908 cites W2097965110 @default.
- W4212810908 cites W2114627400 @default.
- W4212810908 cites W2116205649 @default.
- W4212810908 cites W2124531470 @default.
- W4212810908 cites W2144178804 @default.
- W4212810908 cites W2148878254 @default.
- W4212810908 cites W2166202304 @default.
- W4212810908 cites W2167909421 @default.
- W4212810908 cites W2168342632 @default.
- W4212810908 cites W2204688218 @default.
- W4212810908 cites W2210672989 @default.
- W4212810908 cites W2264105514 @default.
- W4212810908 cites W2268949056 @default.
- W4212810908 cites W2288325680 @default.
- W4212810908 cites W2302688686 @default.
- W4212810908 cites W2313152101 @default.
- W4212810908 cites W2335708867 @default.
- W4212810908 cites W2346880536 @default.
- W4212810908 cites W2415876542 @default.
- W4212810908 cites W2472849417 @default.
- W4212810908 cites W2475371661 @default.
- W4212810908 cites W2486222972 @default.
- W4212810908 cites W2532614692 @default.
- W4212810908 cites W2539494034 @default.
- W4212810908 cites W2546932883 @default.
- W4212810908 cites W2549534101 @default.
- W4212810908 cites W2558260705 @default.
- W4212810908 cites W2575129035 @default.
- W4212810908 cites W2591123944 @default.
- W4212810908 cites W2595858016 @default.
- W4212810908 cites W2608492464 @default.
- W4212810908 cites W2612069645 @default.
- W4212810908 cites W2613460655 @default.
- W4212810908 cites W2615304062 @default.
- W4212810908 cites W2701375372 @default.
- W4212810908 cites W2721426985 @default.
- W4212810908 cites W2734574592 @default.
- W4212810908 cites W2736287258 @default.
- W4212810908 cites W2745638273 @default.
- W4212810908 cites W2748547763 @default.
- W4212810908 cites W2752609999 @default.
- W4212810908 cites W2757709805 @default.
- W4212810908 cites W2757980641 @default.
- W4212810908 cites W2759997926 @default.
- W4212810908 cites W2766872024 @default.
- W4212810908 cites W2771459593 @default.
- W4212810908 cites W2774259180 @default.
- W4212810908 cites W2777277563 @default.
- W4212810908 cites W2777780841 @default.
- W4212810908 cites W2791625547 @default.
- W4212810908 cites W2791880774 @default.
- W4212810908 cites W2793435344 @default.
- W4212810908 cites W2795022655 @default.
- W4212810908 cites W2800258246 @default.
- W4212810908 cites W2807213558 @default.
- W4212810908 cites W2808074209 @default.
- W4212810908 cites W2810166530 @default.
- W4212810908 cites W2810423511 @default.
- W4212810908 cites W2810698630 @default.
- W4212810908 cites W2839544824 @default.
- W4212810908 cites W2888859009 @default.
- W4212810908 cites W2889552839 @default.
- W4212810908 cites W2897917666 @default.
- W4212810908 cites W2904843244 @default.
- W4212810908 cites W2905268342 @default.
- W4212810908 cites W2906921918 @default.
- W4212810908 cites W2908036779 @default.
- W4212810908 cites W2909889681 @default.
- W4212810908 cites W2911360277 @default.