Matches in SemOpenAlex for { <https://semopenalex.org/work/W4212821261> ?p ?o ?g. }
- W4212821261 abstract "Chemotherapy resistance is a critical contributor to cancer mortality and thus an urgent unmet challenge in oncology. To characterize chemotherapy resistance processes in high-grade serous ovarian cancer, we prospectively collected tissue samples before and after chemotherapy and analyzed their transcriptomic profiles at a single-cell resolution. After removing patient-specific signals by a novel analysis approach, PRIMUS, we found a consistent increase in stress-associated cell state during chemotherapy, which was validated by RNA in situ hybridization and bulk RNA sequencing. The stress-associated state exists before chemotherapy, is subclonally enriched during the treatment, and associates with poor progression-free survival. Co-occurrence with an inflammatory cancer–associated fibroblast subtype in tumors implies that chemotherapy is associated with stress response in both cancer cells and stroma, driving a paracrine feed-forward loop. In summary, we have found a resistant state that integrates stromal signaling and subclonal evolution and offers targets to overcome chemotherapy resistance." @default.
- W4212821261 created "2022-02-24" @default.
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- W4212821261 date "2022-02-25" @default.
- W4212821261 modified "2023-10-09" @default.
- W4212821261 title "Longitudinal single-cell RNA-seq analysis reveals stress-promoted chemoresistance in metastatic ovarian cancer" @default.
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- W4212821261 doi "https://doi.org/10.1126/sciadv.abm1831" @default.
- W4212821261 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35196078" @default.